Açar Burak, Yüksel Mahmut, Yayla Çağrı, Kırbaş Özgür, Ünal Sefa, Ertem Ahmet Göktuğ, Demirtaş Koray, Kaplan Mustafa, Akdoğan Meral, Kaçar Sabite, Kayaçetin Ertuğrul, Aydoğdu Sinan
Department of Cardiology, Türkiye Yüksek İhtisas Training and Research Hospital, Ankara, Turkey.
Turk Kardiyol Dern Ars. 2017 Jun;45(4):333-338. doi: 10.5543/tkda.2017.57870.
Autoimmune hepatitis (AIH) is a liver disorder that affects both children and adults. It is characterized by inflammatory liver histology, elevated transaminase level, circulating nonorgan-specific autoantibodies, and increased level of immunoglobulin G in the absence of known etiology. Ventricular repolarization has been evaluated using T wave and QT interval measurements in patients with hepatic cirrhosis. Ventricular repolarization may be defined using QT interval, QT dispersion, and T wave measurements. Recently, it has been demonstrated that peak and end of the T wave (Tp-e) interval, Tp-e/QT, and Tp-e/corrected QT interval (QTc) ratios can be novel indicators for prediction of ventricular arrhythmias and mortality. In this study, an investigation of ventricular repolarization using Tp-e interval and Tp-e/QT ratio in patients with AIH was performed.
Total of 31 patients with AIH and 31 controls were enrolled in the present study. Tp-e interval, Tp-e/QT, and Tp-e/QTc ratios were measured on 12-lead electrocardiogram.
QT interval (378.9±41.4 vs. 350.0±22.7; p=0.001), QTc interval (396.8±46.7 vs. 367.3±34.9; p=0.039), Tp-e interval (68.2±12.3 vs. 42.5±6.8; p<0.001), Tp-e/QT ratio (0.18±0.02 vs. 0.12±0.01; p<0.001) and Tp-e/QTc ratio (0.17±0.02 vs. 0.11±0.01; p<0.001) were significantly higher in patients with AIH than control patients.
The results of the present study indicated that Tp-e interval, Tp-e/QT, and Tp-e/QTc ratios were greater in patients with AIH.
自身免疫性肝炎（AIH）是一种影响儿童和成人的肝脏疾病。其特征为肝脏组织学炎症、转氨酶水平升高、循环中存在非器官特异性自身抗体以及在无已知病因情况下免疫球蛋白G水平升高。已通过测量肝硬化患者的T波和QT间期来评估心室复极。心室复极可通过QT间期、QT离散度和T波测量来定义。最近，已证明T波峰末（Tp-e）间期、Tp-e/QT以及Tp-e/校正QT间期（QTc）比值可作为预测室性心律失常和死亡率的新指标。在本研究中，对AIH患者使用Tp-e间期和Tp-e/QT比值进行了心室复极研究。
本研究共纳入31例AIH患者和31例对照。在12导联心电图上测量Tp-e间期、Tp-e/QT和Tp-e/QTc比值。
AIH患者的QT间期（378.9±41.4对350.0±22.7；p=0.001）、QTc间期（396.8±46.7对367.3±34.9；p=0.039）、Tp-e间期（68.2±12.3对42.5±6.8；p<0.001）、Tp-e/QT比值（0.18±0.02对0.12±0.01；p<0.001）和Tp-e/QTc比值（0.17±0.02对0.11±0.01；p<0.001）均显著高于对照患者。
本研究结果表明，AIH患者的Tp-e间期、Tp-e/QT和Tp-e/QTc比值更大。
