Ku Yunseo, Ahn Joong Woo, Kwon Chiheon, Kim Do Youn, Suh Myung-Whan, Park Moo Kyun, Lee Jun Ho, Oh Seung Ha, Kim Hee Chan
Interdisciplinary Program in Bioengineering, Seoul National University, Seoul, South Korea.
Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University Hospital, Seoul, South Korea.
Hear Res. 2017 May;348:120-128. doi: 10.1016/j.heares.2017.03.003. Epub 2017 Mar 7.
The present study aimed to investigate whether gap-prepulse inhibition (GPI) deficit in patients with tinnitus occurred in the N1-P2 complex of the cortical auditory evoked potential. Auditory late responses to the intense sound of the GPI paradigm were obtained from 16 patients with tinnitus and 18 age- and hearing loss-matched controls without tinnitus. The inhibition degrees of the N1-P2 complex were assessed at 100-, 50-, and 20-ms gap durations with tinnitus-pitch-matched and non-matched frequency background noises. At the 20-ms gap condition with the tinnitus-pitch-matched frequency background noise, only the tinnitus group showed an inhibition deficit of the N1-P2 complex. The inhibition deficits were absent in both groups with longer gap durations. These findings suggested that the effect of tinnitus emerged depending on the cue onset timing and duration of the gap-prepulse. Since inhibition deficits were observed in both groups at the same 20-ms gap condition, but with the tinnitus-pitch-non-matched frequency background noise, the present study did not offer proof of concept for tinnitus filling in the gap. Additional studies on the intrinsic effects of different background frequencies on the gap processing are required in the future.
本研究旨在探讨耳鸣患者的间隔-预脉冲抑制（GPI）缺陷是否出现在皮质听觉诱发电位的N1-P2复合波中。从16例耳鸣患者和18例年龄及听力损失匹配的无耳鸣对照者中获取对GPI范式强声的听觉晚期反应。在100毫秒、50毫秒和20毫秒的间隔持续时间下，使用与耳鸣音调匹配和不匹配的频率背景噪声评估N1-P2复合波的抑制程度。在20毫秒间隔条件下，使用与耳鸣音调匹配的频率背景噪声时，只有耳鸣组表现出N1-P2复合波的抑制缺陷。间隔持续时间较长时，两组均无抑制缺陷。这些发现表明，耳鸣的影响取决于间隔-预脉冲的提示起始时间和持续时间。由于在相同的20毫秒间隔条件下，两组均观察到抑制缺陷，但使用的是与耳鸣音调不匹配的频率背景噪声，因此本研究未提供耳鸣填补间隔的概念验证。未来需要对不同背景频率对间隔处理的内在影响进行更多研究。
