Lee Jae-Hun, Jung Jae Yun, Park Ilyong
Beckman Laser Institute Korea, College of Medicine, Dankook University, Cheonan, Korea.
Department of Otolaryngology Head and Neck Surgery, Dankook University Hospital, Cheonan, Korea.
J Audiol Otol. 2020 Jul;24(3):149-156. doi: 10.7874/jao.2019.00374. Epub 2020 May 14.
The gap prepulse inhibition of the acoustic startle response has been used to screen tinnitus in an animal model. Here, we examined changes in the auditory late response under various conditions of gap prepulse inhibition.
We recruited 19 healthy adults (5 males, 14 females) and their auditory late responses were recorded after various stimuli with or without gap prepulsing. The N1 and P2 responses were selected for analysis. The gap prepulse inhibition was estimated to determine the optimal auditory late response in the gap prepulse paradigm.
We found that the gap per se generated a response that was very similar to the response elicited by sound stimuli. This critically affected the gap associated with the maximal inhibition of the stimulus response. Among the various gap-stimulus intervals (GSIs) between the gap and principal stimulus, the GSI of 150 ms maximally inhibited the response. However, after zero padding was used to minimize artifacts after a P2 response to a gap stimulus, the differences among the GSIs disappeared.
Overall, the data suggest that both the prepulse inhibition and the gap per se should be considered when using the gap prepulse paradigm to assess tinnitus in humans.
听觉惊吓反应的间隔前脉冲抑制已被用于在动物模型中筛查耳鸣。在此，我们研究了在间隔前脉冲抑制的各种条件下听觉晚期反应的变化。
我们招募了19名健康成年人（5名男性，14名女性），并在有或无间隔前脉冲的各种刺激后记录他们的听觉晚期反应。选择N1和P2反应进行分析。估计间隔前脉冲抑制以确定间隔前脉冲范式中的最佳听觉晚期反应。
我们发现间隔本身产生的反应与声音刺激引起的反应非常相似。这严重影响了与刺激反应最大抑制相关的间隔。在间隔与主要刺激之间的各种间隔 - 刺激间隔（GSIs）中，150毫秒的GSI最大程度地抑制了反应。然而，在对间隔刺激的P2反应后使用零填充以最小化伪迹后，GSIs之间的差异消失了。
总体而言，数据表明在使用间隔前脉冲范式评估人类耳鸣时，应同时考虑前脉冲抑制和间隔本身。
