Breedveld F C, Lafeber G J, Siegert C E, Vleeming L J, Cats A
Department of Rheumatology, Academic Hospital Leiden, The Netherlands.
J Rheumatol. 1987 Oct;14(5):1008-12.
The activity of elastase and collagenase was measured in the synovial fluid (SF) of 24 patients with inflammatory and 6 patients with traumatic joint effusions. The enzyme activity was compared with local and systemic variables of the disease. Elastase and collagenase activity could be detected in 79 and 83%, respectively, of the arthritic SF, whereas no enzyme activity was found in the traumatic joint effusions. The SF enzyme activity showed no correlation with clinical, laboratory or radiographic variables of arthritis in the joint from which the fluid was obtained. Our results show that proteolytic enzyme activity in SF may help to distinguish inflammatory from noninflammatory joint effusions but does not reflect the severity of the arthritic process.
在24例炎性关节积液患者和6例创伤性关节积液患者的滑液（SF）中测量了弹性蛋白酶和胶原酶的活性。将酶活性与疾病的局部和全身变量进行了比较。在79%和83%的关节炎滑液中分别检测到弹性蛋白酶和胶原酶活性，而在创伤性关节积液中未发现酶活性。滑液酶活性与获取滑液的关节中关节炎的临床、实验室或影像学变量无关。我们的结果表明，滑液中的蛋白水解酶活性可能有助于区分炎性和非炎性关节积液，但不能反映关节炎进程的严重程度。
