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1例伴有牙根下骨增生的患者发生双膦酸盐相关颌骨坏死。

A Case of Bisphosphonate-Related Osteonecrosis of the Jaw in a Patient with Subpontic Osseous Hyperplasia.

作者信息

Tsuji Chiaki, Watanabe Hiroshi, Nakayama Hidenori, Goto Mitsuo, Kurita Kenichi

机构信息

Department of Oral and Maxillofacial Surgery, School of Dentistry, Aichi Gakuin University, Nagoya, Japan.

出版信息

Case Rep Dent. 2017;2017:9659761. doi: 10.1155/2017/9659761. Epub 2017 Feb 14.

Abstract

Subpontic osseous hyperplasia (SOH) is a growth of bone occurring on the edentulous ridge beneath the pontics of fixed partial dentures (FPDs). This report describes a case of bisphosphonate- (BP-) related osteonecrosis of the jaw (BRONJ) in a SOH patient followed by deciduation of the bony lesion. A 73-year-old woman visited a dental clinic after experiencing pain and swelling beneath the pontics of a FPD that had been inserted 15 years ago. The pontics were removed, but the symptoms persisted and she was referred to our hospital. There was an osseous bulge and gum swelling around the edentulous ridge of teeth 18 and 19, as well as bone exposure. As she had been taking an oral BP for 6 years, we diagnosed this case as stage 2 BRONJ. Following BP withdrawal, the bony lesion detached from the mandible. The tissue was diagnosed as sequestrum based on the histopathological findings. Two months after deciduation, epithelialization over the area of exposed bone was achieved and no recurrence has been observed.

摘要

桥体下骨增生(SOH)是指在固定局部义齿(FPD)桥体下方的无牙嵴上出现的骨质生长。本报告描述了1例桥体下骨增生患者发生双膦酸盐(BP)相关颌骨骨坏死(BRONJ),随后骨病变脱落的病例。一名73岁女性在佩戴已15年的FPD桥体下方出现疼痛和肿胀后前往牙科诊所就诊。桥体被移除,但症状持续存在,随后她被转诊至我院。在18和19号牙的无牙嵴周围有骨隆起和牙龈肿胀,并有骨质暴露。由于她已经口服BP 6年,我们将该病例诊断为2期BRONJ。停用BP后,骨病变与下颌骨分离。根据组织病理学检查结果,该组织被诊断为死骨。骨病变脱落后两个月,暴露骨区域实现了上皮化,且未观察到复发。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5bd7/5329666/aad38bf63354/CRID2017-9659761.001.jpg

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