Vicens Alberto, Andrade-López Karla, Cortez Diego, Gutiérrez Rosa María, Treviño Claudia L
Departamento de Genética del Desarrollo y Fisiología Molecular Instituto de Biotecnología Universidad Nacional Autónoma de México Cuernavaca Morelos México.
Centro de Ciencias Genómicas Universidad Nacional Autónoma de México Cuernavaca Morelos México.
FEBS Open Bio. 2017 Feb 17;7(3):382-390. doi: 10.1002/2211-5463.12186. eCollection 2017 Mar.
Slo3 is a sperm-specific potassium (K) channel essential for male fertility. Slo3 channels have so far been considered to be specific to mammals. Through exploratory genomics, we identified the gene in the genome of terrestrial (birds and reptiles) and aquatic (fish) vertebrates. In the case of fish, has undergone several episodes of gene loss. Transcriptomic analysis showed that vertebrate Slo3 transcript orthologues are predominantly expressed in testis, in concordance with the mammalian Slo3. We conclude that the gene arose during the radiation of early vertebrates, much earlier than previously thought. Our findings add to the growing evidence indicating that the phylogenetic profiles of sperm-specific channels are intermittent throughout metazoan evolution, which probably reflects the adaptation of sperm to different ionic milieus and fertilization environments.
Slo3是一种对雄性生育至关重要的精子特异性钾（K）通道。迄今为止，Slo3通道一直被认为是哺乳动物特有的。通过探索性基因组学，我们在陆生（鸟类和爬行动物）和水生（鱼类）脊椎动物的基因组中鉴定出了该基因。就鱼类而言，该基因经历了几次基因丢失事件。转录组分析表明，脊椎动物Slo3转录本直系同源物主要在睾丸中表达，这与哺乳动物的Slo3一致。我们得出结论，该基因在早期脊椎动物辐射期间出现，比之前认为的要早得多。我们的发现进一步证明，精子特异性通道的系统发育概况在整个后生动物进化过程中是间歇性的，这可能反映了精子对不同离子环境和受精环境的适应。
