Delavar Kasmaei Hossein, Amiri Marzieh, Negida Ahmed, Hajimollarabi Samaneh, Mahdavi Nastaransadat
Department of Neurology, Shohadaye Tajrish Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Department of Emergency Medicine, Shahid Beheshti Hospital, Guilan University of Medical Sciences, Anzali, Iran.
Emerg (Tehran). 2017;5(1):e2. Epub 2017 Jan 8.
Migraine is a common cause of emergency department (ED) visits. To date, there is no recommended drug of choice for pain management of these patients. In the present study, we aimed to evaluate the effectiveness of ketorolac and magnesium sulfate in this regard.
This is a cross-sectional study performed on all 18 - 60 year-old patients, visiting two different EDs with complaint of moderate to severe migraine headache. Patients were treated with 30 mg ketorolac in one hospital and 1 gram magnesium sulfate in the other. Pain scores were assessed on arrival, 1 and 2 hours after drugs administration and quality of pain management was compared between two groups using SPSS 22.
70 patients with the mean age of 36.4 ± 11.4 years were enrolled (51.4% male). The two groups were similar regarding baseline characteristics (p > 0.05). The improvement in pain score in magnesium sulfate group was greater than Ketorolac group after both one hour (6 vs 3; p < 0.001) and two hours (7 vs 5; p < 0.001).
It seems that both ketorolac and magnesium sulfate are significantly effective in pain control of patients with migraine headache presenting to the emergency department. Magnesium sulfate was superior to ketorolac both one and two hours after drug administration.
偏头痛是急诊科就诊的常见原因。迄今为止，对于这些患者的疼痛管理尚无推荐的首选药物。在本研究中，我们旨在评估酮咯酸和硫酸镁在这方面的有效性。
这是一项横断面研究，对所有年龄在18至60岁、因中度至重度偏头痛头痛前往两家不同急诊科就诊的患者进行。在一家医院，患者接受30毫克酮咯酸治疗，在另一家医院，患者接受1克硫酸镁治疗。在患者到达时、给药后1小时和2小时评估疼痛评分，并使用SPSS 22比较两组的疼痛管理质量。
共纳入70例患者，平均年龄为36.4±11.4岁（男性占51.4%）。两组的基线特征相似（p>0.05）。一小时后（6比3；p<0.001）和两小时后（7比5；p<0.001），硫酸镁组的疼痛评分改善均大于酮咯酸组。
似乎酮咯酸和硫酸镁对前往急诊科就诊的偏头痛患者的疼痛控制均有显著效果。给药后1小时和2小时，硫酸镁均优于酮咯酸。
