Salata Cristiano, Calistri Arianna, Parolin Cristina, Baritussio Aldo, Palù Giorgio
a Department of Molecular Medicine , University of Padova , Padova , Italy.
b Clinica Medica 1, Department of Medicine , University of Padova , Padova , Italy.
Expert Rev Anti Infect Ther. 2017 May;15(5):483-492. doi: 10.1080/14787210.2017.1305888. Epub 2017 Mar 20.
Emerging and reemerging viral infections represent a major concern for human and veterinary public health and there is an urgent need for the development of broad-spectrum antivirals. Areas covered: A recent strategy in antiviral research is based on the identification of molecules targeting host functions required for infection of multiple viruses. A number of FDA-approved drugs used to treat several human diseases are cationic amphiphilic drugs (CADs) that have the ability to accumulate inside cells affecting several structures/functions hijacked by viruses during infection. In this review we summarized the CADs' chemical properties and effects on the cells and reported the main FDA-approved CADs that have been identified so far as potential antivirals in drug repurposing studies. Expert commentary: Although there have been concerns regarding the efficacy and the possible side effects of the off-label use of CADs as antivirals, they seem to represent a promising starting point for the development of broad-spectrum antiviral strategies. Further knowledge about their mechanism of action is required to improve their antiviral activity and to reduce the risk of side effects.
新出现和再次出现的病毒感染是人类和兽医公共卫生的主要关注点，因此迫切需要开发广谱抗病毒药物。涵盖领域：抗病毒研究的最新策略基于识别针对多种病毒感染所需宿主功能的分子。一些用于治疗多种人类疾病的FDA批准药物是阳离子两亲性药物（CADs），它们能够在细胞内积累，影响病毒在感染过程中劫持的几种结构/功能。在本综述中，我们总结了CADs的化学性质及其对细胞的影响，并报告了迄今为止在药物重新利用研究中被确定为潜在抗病毒药物的主要FDA批准的CADs。专家评论：尽管人们对将CADs作为抗病毒药物进行非标签使用的疗效和可能的副作用存在担忧，但它们似乎是开发广谱抗病毒策略的一个有希望的起点。需要进一步了解其作用机制，以提高其抗病毒活性并降低副作用风险。
