埃博拉病毒的演变：2013 - 2016年疫情的启示 - Suppr

Holmes Edward C, Dudas Gytis, Rambaut Andrew, Andersen Kristian G

Marie Bashir Institute for Infectious Diseases and Biosecurity, School of Life and Environmental Sciences and Sydney Medical School, Charles Perkins Centre, University of Sydney, Sydney, New South Wales 2006, Australia.

Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.

Nature. 2016 Oct 13;538(7624):193-200. doi: 10.1038/nature19790.

The 2013-2016 epidemic of Ebola virus disease in West Africa was of unprecedented magnitude and changed our perspective on this lethal but sporadically emerging virus. This outbreak also marked the beginning of large-scale real-time molecular epidemiology. Here, we show how evolutionary analyses of Ebola virus genome sequences provided key insights into virus origins, evolution and spread during the epidemic. We provide basic scientists, epidemiologists, medical practitioners and other outbreak responders with an enhanced understanding of the utility and limitations of pathogen genomic sequencing. This will be crucially important in our attempts to track and control future infectious disease outbreaks.

2013 - 2016年西非埃博拉病毒病疫情规模空前，改变了我们对这种致命但偶尔出现的病毒的看法。这次疫情也标志着大规模实时分子流行病学的开端。在此，我们展示了对埃博拉病毒基因组序列的进化分析如何为该病毒在疫情期间的起源、进化和传播提供了关键见解。我们让基础科学家、流行病学家、医学从业者和其他疫情应对人员更好地理解病原体基因组测序的作用和局限性。这对于我们追踪和控制未来传染病疫情的努力至关重要。