通过磺酰氯与脂肪族卤化物的镁介导偶联反应高效合成脂肪族砜。
Efficient synthesis of aliphatic sulfones by Mg mediated coupling reactions of sulfonyl chlorides and aliphatic halides.
作者信息
Fu Ying, Xu Qin-Shan, Li Quan-Zhou, Du Zhengyin, Wang Ke-Hu, Huang Danfeng, Hu Yulai
机构信息
Key Laboratory of Eco-Environment Related Polymer Materials of Ministry of Education, College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou, 730070, China.
出版信息
Org Biomol Chem. 2017 Mar 28;15(13):2841-2845. doi: 10.1039/c7ob00251c.
PMID:28287219
Abstract
Sulfonyl chlorides were reduced to anhydrous sulfinate salts with magnesium under sonication. These sulfinates were alkylated to sulfones with alkyl chlorides in the presence of catalytic sodium iodide under sonication. A variety of aliphatic sulfones was efficiently prepared by this one-pot two-step procedure.
摘要
在超声作用下，磺酰氯与镁反应还原为无水亚磺酸盐。在超声作用下，这些亚磺酸盐在催化量的碘化钠存在下与氯代烃发生烷基化反应生成砜。通过这种一锅两步法能高效制备多种脂肪族砜。
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