Leung John S L, Seto Alfred, Li George K H
a Li Ka Shing Faculty of Medicine , The University of Hong Kong , Pokfulam, Hong Kong SAR , China.
Nutr Cancer. 2017 Apr;69(3):464-469. doi: 10.1080/01635581.2017.1285406. Epub 2017 Feb 17.
Head and neck cancer patients treated with surgery often experience significant postoperative morbidities. Administering preoperative nutritional intervention may improve surgical outcomes, but there is currently a paucity of data reviewing the association between preoperative nutritional status and postoperative outcome. It is therefore of importance to investigate this association among head and neck cancer patients. To assess the association between preoperative nutritional status and postoperative outcome in head and neck cancer patients treated with surgery, a retrospective study of 70 head and neck cancer patients who were surgically treated between 2013 and 2014 in a tertiary referral head and neck surgery center in Hong Kong was conducted. Clinical data regarding preoperative nutritional status and postoperative outcome were retrieved from a computer record system. Logistic and linear regressions were used to analyze the appropriate parameters. A higher preoperative albumin level was associated with lower rates of postoperative complications and better wound healing (P < 0.05). In contrast, preoperative body mass index, hemoglobin level, and absolute lymphocyte count did not demonstrate significant associations with postoperative outcome. As high albumin levels are associated with better surgical outcome in head and neck cancer patients, preoperative intervention strategies that boost albumin levels could be considered for improving surgical outcome.
接受手术治疗的头颈癌患者术后常出现严重的并发症。进行术前营养干预可能会改善手术效果，但目前缺乏关于术前营养状况与术后结果之间关联的数据。因此，对头颈癌患者之间的这种关联进行研究具有重要意义。为了评估接受手术治疗的头颈癌患者术前营养状况与术后结果之间的关联，我们对2013年至2014年在香港一家三级转诊头颈外科中心接受手术治疗的70名头颈癌患者进行了一项回顾性研究。从计算机记录系统中检索了有关术前营养状况和术后结果的临床数据。使用逻辑回归和线性回归分析适当的参数。术前白蛋白水平较高与术后并发症发生率较低和伤口愈合较好相关（P < 0.05）。相比之下，术前体重指数、血红蛋白水平和绝对淋巴细胞计数与术后结果未显示出显著关联。由于高白蛋白水平与头颈癌患者更好的手术结果相关，因此可以考虑采用提高白蛋白水平的术前干预策略来改善手术结果。
