Huang Xuechen, Zheng Kaihui, Kohan Sam, Denprasert Petcharat May, Liao Limin, Loeb Gerald Eli
IEEE Trans Neural Syst Rehabil Eng. 2017 Jul;25(7):1068-1078. doi: 10.1109/TNSRE.2017.2679077. Epub 2017 Mar 7.
We have developed a percutaneously implantable and wireless microstimulator (NuStim) to exercise the pelvic floor muscles for the treatment of stress urinary incontinence. It produces a wide range of charge-regulated electrical stimulation pulses and trains of pulses using a simple electronic circuit that receives power and timing information from an externally generated RF magnetic field. The complete system was validated in vitro and in vivo in preclinical studies demonstrating that the NuStim can be successfully implanted into an effective, low threshold location, and the implant can be operated chronically to produce effective and well-tolerated contractions of skeletal muscle.
我们研发了一种可经皮植入的无线微刺激器（NuStim），用于锻炼盆底肌肉以治疗压力性尿失禁。它使用一个简单的电子电路产生各种电荷调节的电刺激脉冲和脉冲序列，该电路从外部产生的射频磁场接收能量和定时信息。在临床前研究中，该完整系统在体外和体内均得到验证，表明NuStim能够成功植入到有效、低阈值的位置，并且该植入物可以长期运行以产生有效且耐受性良好的骨骼肌收缩。
