Shen Jiajian, Lentz Jarrod M, Hu Yanle, Liu Wei, Morales Danairis Hernandez, Stoker Joshua B, Bues Martin
Department of Radiation Oncology, Mayo Clinic Arizona, Phoenix, AZ, USA.
Radiat Oncol. 2017 Mar 14;12(1):52. doi: 10.1186/s13014-017-0783-2.
The range shifter (RS) is used to treat shallow tumors for a proton pencil beam scanning system (PBS). Adding RS certainly complicates the commissioning of the treatment planning system (TPS) because the spot sizes are significantly enlarged with RS. In this work, we present an efficient method to configure a commercial TPS for a PBS system with a fixed RS.
By combining a spiral delivery with customized control points, we were able to significantly improve measurement efficiency and obtain 250 field size factors (FSF) within three hours. The measured FSFs were used to characterize the proton fluence and fit the parameters for the double-Gaussian fluence model used in the TPS. Extensive validation was performed using FSFs measured in air and in water, absolute doses of spread-out Bragg peak (SOBP) fields, and the dose measurements carried out for patient-specific quality assurance (QA).
The measured in-air FSFs agreed with the model's prediction within 3% for all 250 FSFs, and within 2 for 94% of the FSFs. The agreement between model's prediction and measurement was within 2% for the in-air and in-water FSFs and the absolute doses for SOBP beams. The patient-specific QA of 113 fields showed an excellent gamma passing rates (96.95 ± 2.51%) for the absolute dose comparisons with gamma criteria of 2 mm and 2%.
The excellent agreement between the model's prediction and measurements proved the efficiency and accuracy of the proposed method of using FSFs to characterize the proton fluence and configure the TPS for a PBS system with fixed RS.
射程移位器(RS)用于质子笔形束扫描系统(PBS)治疗浅表肿瘤。添加RS无疑会使治疗计划系统(TPS)的调试变得复杂,因为使用RS时束斑尺寸会显著增大。在本研究中,我们提出了一种有效的方法来配置用于带有固定RS的PBS系统的商用TPS。
通过将螺旋式射野与定制控制点相结合,我们能够显著提高测量效率,并在三小时内获得250个射野大小因子(FSF)。所测量的FSF用于表征质子注量,并拟合TPS中使用的双高斯注量模型的参数。使用在空气中和水中测量的FSF、扩展Bragg峰(SOBP)射野的绝对剂量以及针对患者特定质量保证(QA)进行的剂量测量进行了广泛验证。
对于所有250个FSF,空气中测量的FSF与模型预测值的偏差在3%以内;对于94%的FSF,偏差在2%以内。模型预测值与空气中和水中FSF以及SOBP射野绝对剂量测量值之间的偏差在2%以内。113个射野的患者特定QA在绝对剂量比较中,当γ标准为2 mm和2%时,显示出优异的γ通过率(96.95±2.51%)。
模型预测值与测量值之间的良好一致性证明了所提出的使用FSF表征质子注量并为带有固定RS的PBS系统配置TPS方法的效率和准确性。