Ringenberg Q S, Perry M C, Propert K J, Modeas C, Hirsh V, Weiss R B, Richards F, Graziano S, Green M
Dept. of Medicine, University of Missouri-Columbia, School of Medicine 65212.
Med Pediatr Oncol. 1988;16(1):27-9. doi: 10.1002/mpo.2950160107.
Eighty-seven patients with histologically or cytologically proven non-small-cell carcinoma of the lung were treated with 4'-deoxydoxorubicin (DxDx) 30 mg/m2 every 3 weeks. Three responses (4%), all partial, were observed. All responses occurred in patients with large-cell anaplastic lung cancer and none in squamous or adenocarcinoma histologies (P less than 0.01). The durations of partial response for these three responders were 70, 198+ and 209+ days. The side effects noted were predominantly neutropenia, anemia, and weight loss. In three patients, declines in cardiac ejection fraction of 7%, 12%, and 23% occurred after cumulative drug doses of 150 mg/m2, 150 mg/m2, and 233 mg/m2, respectively. 4'-Deoxydoxorubicin had little activity in non-small-cell lung cancer at the dose used in this study.
