Akin Ibrahim, Nienaber Christoph A
Ibrahim Akin, Medical Faculty Mannheim, University Heidelberg, 68167 Mannheim, Germany.
World J Cardiol. 2017 Feb 26;9(2):139-146. doi: 10.4330/wjc.v9.i2.139.
Non-valvular atrial fibrillation is associated with a significantly increased risk of embolic stroke due to blood clot forming predominantly in the left atrial appendage (LAA). Preventive measures to avoid embolic events are permanent administration of anticoagulants or surgical closure of the LAA. Various clinical trials provide evidence about safety, effectiveness and therapeutic success of LAA occlusion using various cardiac occluder devices. The use of such implants for interventional closure of the LAA is likely to become a valuable alternative for stroke prevention, especially in patients with contraindication for oral anticoagulation as safety, clinical benefit and cost-effectiveness of LAA occlusion has recently been demonstrated.
非瓣膜性心房颤动与栓塞性中风风险显著增加相关，这是由于血栓主要在左心耳（LAA）形成。避免栓塞事件的预防措施是长期服用抗凝剂或手术封闭LAA。各种临床试验提供了关于使用各种心脏封堵器装置进行LAA封堵的安全性、有效性和治疗成功率的证据。使用此类植入物进行LAA介入封堵可能成为预防中风的一种有价值的替代方法，特别是对于口服抗凝有禁忌证的患者，因为最近已证明LAA封堵的安全性、临床益处和成本效益。
