脑N-甲基-D-天冬氨酸受体的调节：σ/苯环己哌啶受体及其外源性和内源性配体的共同机制。
Modulation of brain NMDA receptors: common mechanism of sigma/PCP receptors and their exogenous and endogenous ligands.
作者信息
Sircar R, Samaan H, Nichtenhauser R, Snell L D, Johnson K M, Rivier J, Vale W, Zukin R S, Zukin S R
机构信息
Department of Psychiatry, Albert Einstein College of Medicine, Bronx, NY.
出版信息
NIDA Res Monogr. 1986;75:157-60.
Quantitative autoradiographic distribution patterns of sigma/PCP and NMDA receptors show striking similarities but not in all brain areas. We have identified an endogenous ligand of brain PCP receptors which noncompetitively antagonizes NMDA-induced neurotransmitter release from brain slices. These data support the concept that the sigma/PCP receptor ligands may exert their unique behavioral effects by indirect modulation of NMDA-mediated transmission.
σ/苯环己哌啶（PCP）受体和N-甲基-D-天冬氨酸（NMDA）受体的定量放射自显影分布模式显示出惊人的相似性，但并非在所有脑区都是如此。我们已经鉴定出一种脑PCP受体的内源性配体，它能非竞争性地拮抗NMDA诱导的脑片神经递质释放。这些数据支持了这样一种概念，即σ/PCP受体配体可能通过间接调节NMDA介导的传递来发挥其独特的行为效应。
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