Oka T, Aoki K, Kajiwara M, Ishii K, Kuno Y, Hiranuma T, Matsumiya T
Department of Pharmacology, School of Medicine, Tokai University, Isehara, Japan.
NIDA Res Monogr. 1986;75:259-62.
Enkephalin had been shown to be almost exclusively hydrolyzed by three peptidases in the previous studies. In the present investigation, the relative importance of three enzymes in the inactivation of [Leu5]-enkephalin was examined in three isolated preparations. Results showed that amastatin-sensitive aminopeptidase played the greatest role in both guinea-pig ileum and rat vas deferens while it played the similar role to either phosphoramdidon-sensitive endopeptidase-24.11 or captopril-sensitive peptidyl dipeptidase A in mouse vas deferens.
在先前的研究中已表明脑啡肽几乎完全由三种肽酶水解。在本研究中，在三种离体标本中检测了这三种酶在[亮氨酸5] - 脑啡肽失活中的相对重要性。结果表明，氨肽酶抑制剂敏感的氨肽酶在豚鼠回肠和大鼠输精管中起最大作用，而在小鼠输精管中它与磷酰胺脒敏感的内肽酶-24.11或卡托普利敏感的肽基二肽酶A起相似作用。
