Usefulness of cell kinetics for staging of chronic myeloid leukemia?

In the blood, the labelling index of the immature myeloid cells of one patient out of three decreased progressively from diagnosis to blastic crisis. This parameter deserves more investigation. In the marrow however, the 3H thymidine labelling indexes of the myeloid cells were not useful in predicting the blastic transformation of CML. The colony inhibiting activity of the PMN in CML neither was found to be useful in staging the disease.