Department of Cardiology, University Hospital Magdeburg, Leipziger Straße 44, 39120, Magdeburg, Germany.
Clin Res Cardiol. 2017 Aug;106(8):573-581. doi: 10.1007/s00392-017-1087-0. Epub 2017 Mar 13.
The use of noninvasive diagnostics in coronary artery disease remains underdeveloped. To date, there is no simple and inexpensive method that can lead to a reliable diagnosis. Aside from costly and elaborate imaging techniques, exercise ECG, with its rather moderate sensitivity and specificity, is the main diagnostic method available.
In this prospective study of 109 patients, the diagnostic value of cardiogoniometry (CGM), a three-dimensional, computer-analyzed vector cardiogram, was determined before and after physical stress, and the results were compared with those obtained from a stress test. We also investigated whether the sensitivity and specificity of the classical bicycle stress test could be increased with the addition of measurements obtained by CGM. Coronary angiography was used as a reference method.
CGM had a sensitivity of 39% at rest and 42% after physical stress and a specificity of 63% at rest and 57% after stress. This method was found to be markedly inferior to pre-test probability (sensitivity 53%, specificity 81%), stress ECG (sensitivity 52%, specificity 81%), and resting ECG (sensitivity 50%, specificity 64%). The efficiency of exercise ECG testing was not improved by use of CGM results.
If CGM is to be established as a viable diagnostic method in daily clinical practice, it must undergo further development.
在冠心病的非侵入性诊断中仍有许多未被开发的方法。迄今为止,还没有一种简单、廉价的方法可以进行可靠的诊断。除了昂贵而复杂的成像技术外,运动心电图检查是目前主要的诊断方法,但其敏感性和特异性都相当适中。
在这项对 109 名患者的前瞻性研究中,我们在运动前后分别测定了三维、计算机分析的向量心电图 cardiogoniometry(CGM)的诊断价值,并将结果与应激试验的结果进行了比较。我们还研究了是否可以通过增加 CGM 测量值来提高经典的自行车运动试验的敏感性和特异性。冠状动脉造影术作为参考方法。
CGM 在静息状态下的敏感性为 39%,在运动后为 42%,特异性在静息时为 63%,在运动后为 57%。该方法明显劣于预测试概率(敏感性 53%,特异性 81%)、运动心电图检查(敏感性 52%,特异性 81%)和静息心电图检查(敏感性 50%,特异性 64%)。使用 CGM 结果并没有提高运动心电图检查的效率。
如果 CGM 要成为日常临床实践中可行的诊断方法,它必须进一步发展。