配体与阿片受体结合的分子机制：乙醇的选择性抑制作用？
Molecular mechanisms of ligand binding to opioid receptors: selective inhibition by ethanol?
作者信息
Rapaka R S, Bhargava H N, Renugopalakrishnan V, Collins B J
机构信息
Division of Preclinical Research, National Institute on Drug Abuse, Rockville, MD 20857.
出版信息
NIDA Res Monogr. 1986;75:355-8.
Effects of varying concentrations of ethanol on the conformations of DAGO, a mu-specific opioid ligand were monitored by FT-IR spectroscopy. The binding of 3H-labeled DAGO (mu-agonist) and DSLET (delta-agonist) to opioid receptors in the presence of varying concentrations of alcohol was also determined. The results indicate that the conformational features of the ligands are altered and conformational factors may play a role in ligand-receptor interaction.
通过傅里叶变换红外光谱监测不同浓度乙醇对μ特异性阿片样物质配体DAGO构象的影响。还测定了在不同浓度酒精存在下，3H标记的DAGO（μ激动剂）和DSLET（δ激动剂）与阿片受体的结合情况。结果表明，配体的构象特征发生了改变，构象因素可能在配体-受体相互作用中发挥作用。
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