L-5方案：慢性髓性白血病患者的强化治疗
The L-5 protocol: intensive treatment for patients with chronic myeloid leukemia.
作者信息
Gee T S, Cunningham I, Dowling M D, Chaghanti R, Clarkson B D
出版信息
Boll Ist Sieroter Milan. 1978 Jul 31;57(3):289-93.
An aggressive treatment program combining splenic irradiation, splenectomy and intensive cytotoxic combination chemotherapy was used in 37 patients with Ph1 chromosome positive chronic myelogenous leukemia. Cytogenetic Ph1 chromosome determination on marrow cells revealed a significant but transient decrease in the Ph1 positive cell population in 12/37 (32%) cases. Survival duration appears longer in patients who show a reduction in the Ph1 positive population. Blastic transformation occurred in 18/37 (49%) cases, not different from our historical control.
37例Ph1染色体阳性的慢性粒细胞白血病患者接受了一项积极的治疗方案，该方案联合了脾脏照射、脾切除术和强化细胞毒性联合化疗。对骨髓细胞进行的细胞遗传学Ph1染色体检测显示，在37例患者中有12例（32%）的Ph1阳性细胞群体出现了显著但短暂的减少。Ph1阳性群体减少的患者生存时间似乎更长。18/37例（49%）发生了原始细胞转化，与我们的历史对照无差异。
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