Parsons C G, West D C, Headley P M
Dept. of Physiology, Medical School, Bristol, UK.
NIDA Res Monogr. 1986;75:461-4.
The mu agonist fentanyl and the kappa agonists U-50,488 and tifluadom were tested intravenously in electrophysiological experiments on spinal nociceptive reflexes in anaesthetised, spinalised rats. Responses of single motoneurones to thermal and mechanical stimuli were reduced to a similar degree by both mu and kappa agonists and these effects were reversed by low doses of naloxone.
在对麻醉的去脊髓大鼠的脊髓伤害性反射进行的电生理实验中，静脉注射μ阿片受体激动剂芬太尼以及κ阿片受体激动剂U - 50,488和替氟朵。μ和κ阿片受体激动剂均使单运动神经元对热刺激和机械刺激的反应降低到相似程度，且这些效应可被低剂量纳洛酮逆转。
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