• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Development of delta-opioid receptors in rat brain characterised by [3H]-[D-Pen2,D-Pen5] enkephalin binding.

作者信息

Kitchen I, McDowell J

机构信息

Department of Biochemistry, University of Surrey, Guildford, U.K.

出版信息

NIDA Res Monogr. 1986;75:67-8.

PMID:2829009
Abstract

The development of rat brain delta-opioid receptors has been studied in the postnatal period using the highly selective delta-site ligand [3H]-[D-Pen2, D-Pen5] enkephalin (DPDPE) in binding studies. Between day 10 and day 25 there was a three-fold increase in the number of binding sites (expressed per mg protein) and the KD was constant throughout the postnatal period. Specific binding could not be detected earlier than day 10.

摘要

相似文献

1
Development of delta-opioid receptors in rat brain characterised by [3H]-[D-Pen2,D-Pen5] enkephalin binding.
NIDA Res Monogr. 1986;75:67-8.
2
[D-Pen2,4'-125I-Phe4,D-Pen5]enkephalin: a selective high affinity radioligand for delta opioid receptors with exceptional specific activity.[D-青霉胺2,4'-125I-苯丙氨酸4,D-青霉胺5]脑啡肽：一种对δ阿片受体具有选择性高亲和力且比活度极高的放射性配体。
J Pharmacol Exp Ther. 1991 Sep;258(3):1077-83.
3
Binding characteristics of [D-Ala2-MePhe4-Glyol5] enkephalin and [D-Pen2,D-Pen5] enkephalin in rat brain: inhibition studies with fentanyl-like drugs.
NIDA Res Monogr. 1986;75:64-6.
4
Postnatal development of delta-opioid receptor subtypes in mice.小鼠中δ-阿片受体亚型的产后发育
Br J Pharmacol. 1997 Mar;120(6):989-94. doi: 10.1038/sj.bjp.0700990.
5
Ontogenesis of delta-opioid receptors in rat brain using [3H][D-Pen2,D-Pen5]enkephalin as a binding ligand.以[3H][D-青霉胺2，D-青霉胺5]脑啡肽作为结合配体研究大鼠脑中δ-阿片受体的个体发生。
Eur J Pharmacol. 1986 Sep 9;128(3):287-9. doi: 10.1016/0014-2999(86)90780-6.
6
[3H]-[H-D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2] ([3H]CTOP), a potent and highly selective peptide for mu opioid receptors in rat brain.[3H]-[H-D-苯丙氨酸-半胱氨酸-酪氨酸-D-色氨酸-鸟氨酸-苏氨酸-青霉胺-苏氨酸-NH2]（[3H]CTOP），一种对大鼠脑内μ阿片受体具有强效且高度选择性的肽。
J Pharmacol Exp Ther. 1989 Jan;248(1):73-80.
7
Light microscopic autoradiographic localization of delta opioid receptors in the rat brain using a highly selective bis-penicillamine cyclic enkephalin analog.使用高选择性双青霉胺环脑啡肽类似物对大鼠脑中δ阿片受体进行光镜放射自显影定位。
J Pharmacol Exp Ther. 1986 Aug;238(2):720-6.
8
Stress prevents the chronic ethanol-induced delta opiod receptor supersensitivity in the rat brain.应激可防止大鼠大脑中慢性乙醇诱导的δ阿片受体超敏反应。
Pol J Pharmacol Pharm. 1990 Mar-Apr;42(2):137-42.
9
Characterization of [3H][2-D-penicillamine, 5-D-penicillamine]-enkephalin binding to delta opiate receptors in the rat brain and neuroblastoma--glioma hybrid cell line (NG 108-15).[3H][2-D-青霉胺，5-D-青霉胺]脑啡肽与大鼠脑及神经母细胞瘤-胶质瘤杂交细胞系（NG 108-15）中δ阿片受体结合的特性研究
Proc Natl Acad Sci U S A. 1985 Apr;82(8):2543-7. doi: 10.1073/pnas.82.8.2543.
10
Characterization of D-Ala2,Leu5,Cys6-enkephalin: a novel synthetic opioid peptide with slowed dissociation from delta receptors.D-丙氨酸2、亮氨酸5、半胱氨酸6-脑啡肽的特性：一种从δ受体解离缓慢的新型合成阿片肽。
NIDA Res Monogr. 1986;75:193-6.

引用本文的文献

1
Opioid depression of respiration in neonatal rats.
J Physiol. 1995 Jun 15;485 ( Pt 3)(Pt 3):845-55. doi: 10.1113/jphysiol.1995.sp020774.