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慢性肾脏病患者贫血管理的新方法:罗沙司他综述

A New Approach to the Management of Anemia in CKD Patients: A Review on Roxadustat.

作者信息

Becker Kimberly, Saad Maha

机构信息

St. John's University, Jamaica, NY, USA.

出版信息

Adv Ther. 2017 Apr;34(4):848-853. doi: 10.1007/s12325-017-0508-9. Epub 2017 Mar 13.

DOI:10.1007/s12325-017-0508-9
PMID:28290095
Abstract

This article informs the reader of the current information available on a novel therapeutic agent and new class of drug for the treatment of anemia. The data show promising results for alternative erythropoietin-stimulating agents and offers a time line of when Phase III data will be available. The information on this new drug and new drug class will change how nephrologists approach treating anemia within their patients.

摘要

本文向读者介绍了一种用于治疗贫血的新型治疗药物及新一类药物的现有信息。数据显示替代促红细胞生成素刺激剂取得了有前景的结果,并给出了三期数据将公布的时间线。关于这种新药及新一类药物的信息将改变肾病学家治疗患者贫血的方式。

相似文献

1
A New Approach to the Management of Anemia in CKD Patients: A Review on Roxadustat.慢性肾脏病患者贫血管理的新方法:罗沙司他综述
Adv Ther. 2017 Apr;34(4):848-853. doi: 10.1007/s12325-017-0508-9. Epub 2017 Mar 13.
2
Phase 3, Randomized, Double-Blind, Active-Comparator (Darbepoetin Alfa) Study of Oral Roxadustat in CKD Patients with Anemia on Hemodialysis in Japan.日本血液透析慢性肾脏病贫血患者罗沙司他的 3 期、随机、双盲、阳性对照(达贝泊汀α)研究。
J Am Soc Nephrol. 2020 Jul;31(7):1628-1639. doi: 10.1681/ASN.2019060623. Epub 2020 Jun 3.
3
Roxadustat for Treating Anemia in Patients with CKD Not on Dialysis: Results from a Randomized Phase 3 Study.罗沙司他治疗未透析慢性肾脏病患者贫血的随机 3 期研究结果。
J Am Soc Nephrol. 2021 Mar;32(3):737-755. doi: 10.1681/ASN.2020081150. Epub 2021 Feb 10.
4
A Phase 3, Multicenter, Randomized, Two-Arm, Open-Label Study of Intermittent Oral Dosing of Roxadustat for the Treatment of Anemia in Japanese Erythropoiesis-Stimulating Agent-Naïve Chronic Kidney Disease Patients Not on Dialysis.一项评估罗沙司他间歇口服给药治疗未接受透析的非透析慢性肾脏病且对红细胞生成刺激剂初治的日本贫血患者的 3 期、多中心、随机、双盲、开放性研究
Nephron. 2020;144(8):372-382. doi: 10.1159/000508100. Epub 2020 Jun 24.
5
Roxadustat for Anemia in Patients with Kidney Disease Not Receiving Dialysis.罗沙司他治疗未接受透析的肾病患者的贫血。
N Engl J Med. 2019 Sep 12;381(11):1001-1010. doi: 10.1056/NEJMoa1813599. Epub 2019 Jul 24.
6
Roxadustat in the treatment of anaemia in chronic kidney disease.罗沙司他用于治疗慢性肾脏病贫血
Expert Opin Investig Drugs. 2018 Jan;27(1):125-133. doi: 10.1080/13543784.2018.1417386. Epub 2017 Dec 25.
7
Roxadustat Treatment for Anemia in Patients Undergoing Long-Term Dialysis.罗沙司他治疗长期透析患者的贫血。
N Engl J Med. 2019 Sep 12;381(11):1011-1022. doi: 10.1056/NEJMoa1901713. Epub 2019 Jul 24.
8
Short-term effect of low-dose roxadustat combined with erythropoiesis-stimulating agent treatment for erythropoietin-resistant anemia in patients undergoing maintenance hemodialysis.维持性血液透析患者低剂量罗沙司他联合促红细胞生成素治疗抵抗性贫血的短期疗效。
Front Endocrinol (Lausanne). 2024 Jul 1;15:1372150. doi: 10.3389/fendo.2024.1372150. eCollection 2024.
9
Roxadustat for the treatment of anemia in patients with chronic kidney diseases: a meta-analysis.罗沙司他治疗慢性肾脏病患者贫血的疗效:一项荟萃分析。
Aging (Albany NY). 2021 Jun 11;13(13):17914-17929. doi: 10.18632/aging.203143.
10
Oral Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitor Roxadustat (FG-4592) for the Treatment of Anemia in Patients with CKD.口服低氧诱导因子脯氨酰羟化酶抑制剂罗沙司他(FG-4592)用于治疗慢性肾脏病患者的贫血
Clin J Am Soc Nephrol. 2016 Jun 6;11(6):982-991. doi: 10.2215/CJN.06890615. Epub 2016 Apr 19.

引用本文的文献

1
Activation of the hypoxia-inducible factor pathway by roxadustat improves glucose metabolism in human primary myotubes from men.罗沙司他激活低氧诱导因子通路可改善男性原代肌管的葡萄糖代谢。
Diabetologia. 2024 Sep;67(9):1943-1954. doi: 10.1007/s00125-024-06185-6. Epub 2024 May 30.
2
Influencing factors of clinical efficacy of roxadustat among hemodialysis patients.罗沙司他治疗血液透析患者的临床疗效影响因素。
Ren Fail. 2024 Dec;46(1):2308701. doi: 10.1080/0886022X.2024.2308701. Epub 2024 Feb 12.
3
Evaluating the effect of Roxadustat on ventricular repolarization in patients undergoing peritoneal dialysis.
评估罗沙司他对腹膜透析患者心室复极的影响。
Eur J Med Res. 2023 Oct 11;28(1):417. doi: 10.1186/s40001-023-01368-0.
4
A critical review of Roxadustat formulations, solid state studies, and analytical methodology.罗沙司他制剂、固态研究及分析方法的批判性综述。
Heliyon. 2023 Jun 1;9(6):e16595. doi: 10.1016/j.heliyon.2023.e16595. eCollection 2023 Jun.
5
Response to roxadustat in a patient undergoing long-term dialysis and allergic to erythropoiesis-stimulating agents: A case report.一名长期透析且对促红细胞生成素刺激剂过敏的患者对罗沙司他的反应:病例报告
World J Clin Cases. 2022 Dec 16;10(35):13122-13128. doi: 10.12998/wjcc.v10.i35.13122.
6
Roxadustat: Not just for anemia.罗沙司他:不止用于贫血。
Front Pharmacol. 2022 Aug 29;13:971795. doi: 10.3389/fphar.2022.971795. eCollection 2022.
7
Roxadustat Attenuates the Disruption of Epithelial Tight Junction in Caco2 Cells and a Rat Model of CKD Through MicroRNA-223.罗沙司他通过微小RNA-223减轻Caco2细胞和慢性肾脏病大鼠模型中上皮紧密连接的破坏。
Front Med (Lausanne). 2022 Apr 13;9:850966. doi: 10.3389/fmed.2022.850966. eCollection 2022.
8
The efficacy and safety of roxadustat for the treatment of anemia in non-dialysis dependent chronic kidney disease patients: An updated systematic review and meta-analysis of randomized clinical trials.罗沙司他治疗非透析依赖性慢性肾脏病患者贫血的疗效和安全性:一项更新的系统评价和随机临床试验荟萃分析。
PLoS One. 2022 Apr 1;17(4):e0266243. doi: 10.1371/journal.pone.0266243. eCollection 2022.
9
Population pharmacokinetics of roxadustat in Japanese dialysis-dependent chronic kidney disease patients with anaemia.罗沙司他在日本透析依赖性慢性肾脏病贫血患者中的群体药代动力学。
Br J Clin Pharmacol. 2022 Feb;88(2):787-797. doi: 10.1111/bcp.15023. Epub 2021 Sep 2.
10
Roxadustat for the treatment of anemia in patients with chronic kidney diseases: a meta-analysis.罗沙司他治疗慢性肾脏病患者贫血的疗效:一项荟萃分析。
Aging (Albany NY). 2021 Jun 11;13(13):17914-17929. doi: 10.18632/aging.203143.