Laatikainen T, Virtanen T, Räisänen I, Salminen K
Department I of Obstetrics and Gynecology, Helsinki University Central Hospital, Finland.
Neuropeptides. 1987 Nov-Dec;10(4):343-53. doi: 10.1016/s0143-4179(87)90101-6.
Concentrations of immunoreactive corticotropin releasing factor (CRF) and corticotropin (ACTH) in the plasma were studied in healthy pregnant women. Concentration of CRF was near the detection limit of the assay (2.5 pmol/l) until the 16th week of pregnancy, increasing thereafter significantly towards term: the mean values (+/- S.E.) at weeks 8-11, 12-15, 16-19, 20-23, 24-27, 28-31, 32-35, and 36-40 were 2.9 +/- 0.42, 2.9 +/- 0.72, 5.2 +/- 1.1, 10.2 +/- 5.8, 14.6 +/- 2.0, 32.8 +/- 4.8, 63.6 +/- 9.2, and 187 +/- 39 pmol/l, respectively. The mean concentration of CRF did not increase during labor, and it decreased rapidly after delivery. On the contrary, the mean plasma level of ACTH increased only slightly during late pregnancy, but during labor the increase was significant. These findings suggest that CRF in maternal circulation is not primarily involved in the regulation of maternal ACTH secretion, and the stress of labor does not increase the release of CRF, which probably originates mainly from the placenta.
对健康孕妇血浆中免疫反应性促肾上腺皮质激素释放因子（CRF）和促肾上腺皮质激素（ACTH）的浓度进行了研究。在妊娠第16周之前，CRF浓度接近检测限（2.5 pmol/l），此后直至足月显著升高：妊娠第8 - 11周、12 - 15周、16 - 19周、20 - 23周、24 - 27周、28 - 31周、32 - 35周和36 - 40周的平均值（±标准误）分别为2.9±0.42、2.9±0.72、5.2±1.1、10.2±5.8、14.6±2.0、32.8±4.8、63.6±9.2和187±39 pmol/l。CRF的平均浓度在分娩过程中没有增加，产后迅速下降。相反，ACTH的平均血浆水平在妊娠晚期仅略有升高，但在分娩过程中升高显著。这些发现表明，母体循环中的CRF并非主要参与母体ACTH分泌的调节，分娩应激并不会增加CRF的释放，CRF可能主要来源于胎盘。
