以还原氨基吡啶席夫碱及其衍生物为配体的铂（II）配合物的合成、表征及细胞毒性研究
Synthesis characterization and cytotoxicity studies of platinum(II) complexes with reduced amino pyridine schiff base and its derivatives as ligands.
作者信息
Li Li-Jun, Yan Qin-Qin, Liu Guo-Jun, Yuan Zhen, Lv Zhen-Hua, Fu Bin, Han Yan-Jun, Du Jian-Long
机构信息
a Chemical Biology Key Laboratory of Hebei Province , Hebei University , Baoding , P.R. China.
出版信息
Biosci Biotechnol Biochem. 2017 Jun;81(6):1081-1089. doi: 10.1080/09168451.2016.1259550. Epub 2017 Mar 14.
A series of reduced amino pyridine Schiff base platinum(II) complexes were prepared as potential anticancer drugs, and characterized by NMR, IR spectroscopy, elemental analysis, and molar conductivity. UV and CD results showed the binding mode between these compounds and salmon sperm DNA may be intercalation. The cytotoxicity of these complexes was validated against A549, Hela, and MCF-7 cell lines by MTT assay. Some complexes exhibited better cytotoxic activity than cisplatin against Hela and MCF-7 cell lines.
制备了一系列还原氨基吡啶席夫碱铂（II）配合物作为潜在的抗癌药物，并通过核磁共振（NMR）、红外光谱（IR）、元素分析和摩尔电导率对其进行了表征。紫外（UV）和圆二色（CD）结果表明，这些化合物与鲑鱼精DNA之间的结合模式可能是嵌入。通过MTT法验证了这些配合物对A549、Hela和MCF-7细胞系的细胞毒性。一些配合物对Hela和MCF-7细胞系表现出比顺铂更好的细胞毒性活性。
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