Morozova T E, Yudina I Y
I.M. Sechenov First Moscow State Medical University, Moscow, Russia.
Kardiologiia. 2016 Sep;56(9):80-83. doi: 10.18565/cardio.2016.9.80-83.
Diuretic drugs - one of the most frequently prescribed groups of drugs in cardiology practice, primarily in patients with arterial hypertension (AH) and chronic heart failure (CHF). The article discusses the features of thiazide and loop diuretics, questions the selection of individual representatives of this class of drugs. Particular attention is paid to the loop diuretic torasemide, possessing, in addition to antihypertensive and diuretic effects, additional features such as the ability to reduce the activity of the renin-angiotensin-aldosterone system, reduce the severity of myocardial fibrosis, no negative influence on lipid and carbohydrate exchange, uric acid levels and blood electrolytes.
利尿药——心脏病学实践中最常处方的药物类别之一,主要用于治疗动脉高血压(AH)和慢性心力衰竭(CHF)患者。本文讨论了噻嗪类利尿剂和袢利尿剂的特点,对这类药物个别代表的选择提出了疑问。特别关注了袢利尿剂托拉塞米,它除了具有抗高血压和利尿作用外,还具有其他特性,如降低肾素-血管紧张素-醛固酮系统活性、减轻心肌纤维化严重程度、对脂质和碳水化合物代谢、尿酸水平及血液电解质无负面影响。