Ostroumova O D, Zykova A A
Sechenov First Moscow State Medical University, Moscow, Russia.
A.I. Evdokimov Moscow State University of Medicine and Dentistry, Moscow, Russia.
Kardiologiia. 2016 Oct;56(10):72-79. doi: 10.18565/cardio.2016.10.72-79.
The article is devoted to the of prevalence, diagnosis, and prognostic significance of renal damage in metabolic syndrome. The pathogenetic mechanisms of development and progression of chronic kidney disease in individuals with obesity, including the role of increased activity of the sympathetic nervous system is discussed. Approaches to the choice of antihypertensive drugs with an emphasis on metabolic and renal protection properties are given. The advantages of imidazoline receptors in neuroprotective of moxonidine in patients with arterial hypertension, metabolic syndrome, and diabetes mellitus is discussed in detail. number of mechanisms of renal protection actions of the agonists of imidazoline receptors is described.
本文致力于探讨代谢综合征中肾脏损害的患病率、诊断及预后意义。讨论了肥胖个体慢性肾脏病发生和进展的发病机制,包括交感神经系统活性增加的作用。给出了选择具有代谢和肾脏保护特性的抗高血压药物的方法。详细讨论了莫索尼定对动脉高血压、代谢综合征和糖尿病患者的咪唑啉受体神经保护作用的优势。描述了咪唑啉受体激动剂肾脏保护作用的多种机制。