Podzolkov V I, Bragina A E, Murashko N F
Sechenov First Moscow State Medical University, Moscow, Russia.
Kardiologiia. 2016 Jul;56(7):14-19. doi: 10.18565/cardio.2016.7.14-19.
to investigate levels of the stable nitric oxide metabolites (NOx) in hypertensive patients with obesity and hyperleptinemia.
We examined 124 untreated patients (45 men and 79 women) with essential hypertension (EH) (mean age 51.4+/-6.5 years, mean hypertension duration 8.5+/-7.6 years, 64% with visceral obesity) and 25 healthy volunteers (10 men and 15 women with comparable age).
NOx levels were significantly higher in hypertensives (43.18+/-21 mol/l) then in controls (28.3+/-9.6 mol/l; p=0.01). Obese hypertensives had lower NOx concentration than nonobese hypertensives (38.8+/-17.9 and 48.5+/-24.7 mol/l, respectively; <0.05). With increase of degree of obesity NOx levels decreased significantly (r=-0.3; p<0.05). NOx levels correlated with presence (r=-0.44; p<0,05) and degree of obesity (r=-0.3; p<0.05). Hypertensives with high leptin levels had lower NOx concentration (29+/-12.2 mol/l), compared to hypertensives with normal leptin levels (34. 7+/-10.5 mol/l) (p<0.05).
研究肥胖合并高瘦素血症高血压患者体内稳定一氧化氮代谢产物（NOx）水平。
我们检查了124例未经治疗的原发性高血压（EH）患者（45例男性和79例女性）（平均年龄51.4±6.5岁，平均高血压病程8.5±7.6年，64%伴有内脏肥胖）以及25名健康志愿者（10名男性和15名女性，年龄相仿）。
高血压患者的NOx水平（43.18±21 μmol/l）显著高于对照组（28.3±9.6 μmol/l；p = 0.01）。肥胖高血压患者的NOx浓度低于非肥胖高血压患者（分别为38.8±17.9和48.5±24.7 μmol/l；p<0.05）。随着肥胖程度增加，NOx水平显著降低（r = -0.3；p<0.05）。NOx水平与肥胖的存在（r = -0.44；p<0.05）及肥胖程度（r = -0.3；p<0.05）相关。瘦素水平高的高血压患者的NOx浓度（29±12.2 μmol/l）低于瘦素水平正常的高血压患者（34.7±10.5 μmol/l）（p<0.05）。
