Yamaguchi Sayaka, Miyagi Takuya, Sogabe Yoko, Yasuda Masahito, Kanazawa Nobuo, Utani Atsushi, Izaki Seiichi, Uezato Hiroshi, Takahashi Kenzo
*Department of Dermatology, University of the Ryukyus, Okinawa, Japan; †Department of Dermatology, Tone-chuo Hospital, Numata, Japan; ‡Department of Dermatology, Gunma University, Maebashi, Japan; §Department of Dermatology, Wakayama Medical University, Wakayama, Japan; ¶Department of Dermatology, Nagasaki University, Nagasaki, Japan; and ‖Department of Dermatology, Saitama Medical University Saitama Medical Center, Kawagoe, Japan.
Am J Dermatopathol. 2017 Jun;39(6):428-432. doi: 10.1097/DAD.0000000000000654.
Pellagra is a nutrient deficiency disease caused by insufficient niacin levels. Recent studies have shown that numbers of epidermal Langerhans cells decreased in other diseases caused by nutritional deficiencies, including necrolytic migratory erythema and acrodermatitis enteropathica. Epidermal Langerhans cells are capable of modulating or even halting the inflammatory reaction. The aim of this study was to examine changes in the number of Langerhans cells and other dendritic cells, and maturation of epidermal Langerhans cells in the lesional and adjacent non-lesional skin in pellagra patients. Seven pellagra patients and 10 healthy individuals who served as controls were included. The number and distribution of dendritic cells and other cutaneous cells were examined by immunohistochemistry. Epidermal Langerhans cells decreased considerably in the skin lesions of pellagra patients, whereas other dendritic cells did not change. The decrease in the number of Langerhans cells was positively correlated with the histological severity of skin lesions. As the number of Langerhans cells was not reduced in the undisturbed neighboring skin, the depletion of epidermal Langerhans cells did not precede skin damage but was a cause of prolonged severe inflammation.
糙皮病是一种由烟酸水平不足引起的营养缺乏病。最近的研究表明，在包括坏死性游走性红斑和肠病性肢端皮炎在内的其他营养缺乏引起的疾病中，表皮朗格汉斯细胞数量减少。表皮朗格汉斯细胞能够调节甚至阻止炎症反应。本研究的目的是检查糙皮病患者皮损及相邻非皮损皮肤中朗格汉斯细胞和其他树突状细胞数量的变化以及表皮朗格汉斯细胞的成熟情况。研究纳入了7例糙皮病患者和10名作为对照的健康个体。通过免疫组织化学检查树突状细胞和其他皮肤细胞的数量及分布。糙皮病患者皮肤病变中表皮朗格汉斯细胞显著减少，而其他树突状细胞没有变化。朗格汉斯细胞数量的减少与皮肤病变的组织学严重程度呈正相关。由于未受影响的邻近皮肤中朗格汉斯细胞数量未减少，表皮朗格汉斯细胞的耗竭并非先于皮肤损伤，而是长期严重炎症的一个原因。
