Astaf'eva L I, Kalinin P L, Kadashev B A
Burdenko Neurosurgical Institute, Moscow, Russia.
Zh Vopr Neirokhir Im N N Burdenko. 2017;81(1):58-62. doi: 10.17116/neiro201780758-62.
Acromegaly is a severe disease associated with chronic overproduction of the growth hormone (GH) and insulin-like growth factor-1 (IGF-1), which is caused in most cases by pituitary adenoma. The main causes of mortality in acromegaly are cardiovascular diseases, respiratory diseases, and cancers. At present, the most effective treatment for acromegaly is surgical pituitary adenomectomy. Complete resection of pituitary tumors leads to the normalization of GH and IGF-1 levels, regression of symptoms, and a reduction in the risk of death. The article discusses the current criteria for diagnosis and remission of acromegaly after surgical adenomectomy as well as postoperative monitoring issues aligned with the recent guidelines of the Russian and international endocrinology associations.
肢端肥大症是一种严重疾病,与生长激素(GH)和胰岛素样生长因子-1(IGF-1)长期过度分泌有关,多数情况下由垂体腺瘤引起。肢端肥大症患者的主要死亡原因是心血管疾病、呼吸系统疾病和癌症。目前,治疗肢端肥大症最有效的方法是垂体腺瘤切除术。垂体肿瘤的完全切除可使GH和IGF-1水平恢复正常,症状消退,并降低死亡风险。本文讨论了垂体腺瘤切除术后肢端肥大症的当前诊断和缓解标准,以及与俄罗斯和国际内分泌协会最新指南一致的术后监测问题。