Harnod Tomor, Wang Yu-Chiao, Lin Cheng-Li, Tseng Chun-Hung
Department of Neurosurgery, Hualien Tzu Chi General Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan.
College of Medicine, Tzu Chi University, Hualien, Taiwan.
PLoS One. 2017 Mar 14;12(3):e0173491. doi: 10.1371/journal.pone.0173491. eCollection 2017.
Sleep-disordered breathing (SDB) is often associated with other medical disorders. Whether SDB interacts with other factors for developing subsequent epilepsy remains unclear.
This population-based cohort study was conducted using the National Health Insurance Research Database of Taiwan. Patients aged >20 years and diagnosed with SDB between 2000 and 2010 comprised the SDB cohort (n = 138,507), and their data were compared with those of the comparison cohort (n = 138,507). The adjusted hazard ratio (aHR) for epilepsy was calculated using a multivariate Cox proportional hazards model.
The SDB cohort had an increased risk of epilepsy (aHR = 1.50, 95% confidence interval [CI] = 1.36-1.66). The sex-stratified analysis revealed a significant adjusted hazard ratio (aHR) for epilepsy with a 1.51-fold higher risk for female patients, and also a significantly 1.49-fold higher risk for male patients in the SDB cohort. Although epilepsy incidence increased with age in both cohorts, different age groups in the SDB cohort all had a significantly higher risk of developing epilepsy than comparison cohort.
This population-based cohort study indicates that patients with SDB are at a high risk of developing subsequent epilepsy, in both sexes and all age groups.
睡眠呼吸障碍（SDB）常与其他医学病症相关。SDB是否与其他因素相互作用导致后续癫痫尚不清楚。
本基于人群的队列研究使用台湾国民健康保险研究数据库进行。2000年至2010年间年龄大于20岁且被诊断为SDB的患者组成SDB队列（n = 138,507），并将他们的数据与对照队列（n = 138,507）的数据进行比较。使用多变量Cox比例风险模型计算癫痫的调整风险比（aHR）。
SDB队列患癫痫的风险增加（aHR = 1.50，95%置信区间[CI] = 1.36 - 1.66）。按性别分层分析显示，SDB队列中女性患者癫痫的调整风险比（aHR）显著升高，风险高出1.51倍，男性患者风险也显著高出1.49倍。尽管两个队列中癫痫发病率均随年龄增加，但SDB队列中不同年龄组患癫痫的风险均显著高于对照队列。
这项基于人群的队列研究表明，SDB患者无论男女及各年龄组，发生后续癫痫的风险都很高。
