Porcaro Antonio B, Corsi Paolo, de Luyk Nicolò, Sebben Marco, Tafuri Alessandro, Bizzotto Leonardo, Cacciamani Giovanni, De Marchi Davide, Processali Tania, Mattevi Daniele, Novella Giovanni, Cerruto Maria A, Brunelli Matteo, Siracusano Salvatore, Artibani Walter
Urologic Clinic, University Hospital, Ospedale Polo Chirurgico Borgo Trento, Azienda Ospedaliera Universitaria Integrata, Verona - Italy.
Department of Pathology, University Hospital, Ospedale Polo Chirurgico Borgo Trento, Azienda Ospedaliera Universitaria Integrata, Verona - Italy.
Tumori. 2017 Jul 31;103(4):374-379. doi: 10.5301/tj.5000607. Epub 2017 Feb 28.
To investigate prostate volume index (PVI), defined as the ratio of volume of the transitional zone on that of the peripheral zone, as a factor stratifying prostate cancer (PCA) risk in patients elected to a first random biopsy set.
The study evaluated 596 patients who were elected to a first random biopsy set because of suspected PCA in a period between September 2010 and September 2015. Prostate volume index was dichotomized to PVI ≤1 vs PVI >1. The multivariate logistic regression model investigated clinical factors with dichotomized PVI associating with PCA.
The detection rate of PCA was 49%. The dichotomized PVI >1 stratified PCA risk (odds ratio [OR] 0.455; p<0.0001) beyond age (OR 1.062; p<0.0001), PSA (OR 1.167; p<0.0001), PV (OR 0.957; p<0.0001), and abnormal digital rectal examination (OR 2.094; p<0.0001). The goodness of fit statistics assessed model efficacy.
A large cohort of patients elected to a first random biopsy set had PCA risk stratified by dichotomized PVI beyond other clinical independent factors. Confirmatory studies are required.
研究前列腺体积指数（PVI），即移行区体积与外周区体积之比，作为首次随机活检患者前列腺癌（PCA）风险分层的一个因素。
本研究评估了2010年9月至2015年9月期间因疑似PCA而入选首次随机活检的596例患者。将前列腺体积指数分为PVI≤1和PVI>1两组。多因素逻辑回归模型研究了二分法PVI与PCA相关的临床因素。
PCA的检出率为49%。二分法PVI>1对PCA风险的分层（优势比[OR]0.455；p<0.0001）超过了年龄（OR 1.062；p<0.0001）、前列腺特异性抗原（PSA）（OR 1.167；p<0.0001）、前列腺体积（PV）（OR 0.957；p<0.0001）和直肠指检异常（OR 2.094；p<0.0001）。拟合优度统计评估了模型的有效性。
大量入选首次随机活检的患者中，二分法PVI对PCA风险的分层超过了其他临床独立因素。需要进行验证性研究。
