前列腺癌肿瘤分级组中前列腺慢性炎症的负相关：对入选首次随机活检组的738例连续病例的回顾性研究。

Inverse Association of Prostatic Chronic Inflammation among Prostate Cancer Tumor Grade Groups: Retrospective Study of 738 Consecutive Cases Elected to a First Random Biopsy Set.

作者信息

Porcaro Antonio Benito, Tafuri Alessandro, Novella Giovanni, Sebben Marco, Mariotto Arianna, Inverardi Davide, Corsi Paolo, Processali Tania, Pirozzi Marco, Amigoni Nelia, Rizzetto Riccardo, Brunelli Matteo, Balzarro Matteo, Siracusano Salvatore, Artibani Walter

机构信息

Urologic Clinic, University Hospital, Ospedale Policlinico, Azienda Ospedaliera Universitaria Integrata, Verona, Italy.

Department of Pathology, University Hospital, Ospedale Policlinico, Azienda Ospedaliera Universitaria Integrata, Verona, Italy.

出版信息

Urol Int. 2018;100(4):456-462. doi: 10.1159/000488882. Epub 2018 Apr 19.

DOI:10.1159/000488882

PMID:29672311

Abstract

OBJECTIVES

The study aimed to evaluate associations of prostatic chronic inflammation (PCI) with prostate cancer (PCA) grade groups by the International Society of Urological Pathology (ISUP).

METHODS

The study evaluated retrospectively 738 cases. The patient population was sampled into 3 groups collecting cases without and with PCA including subjects with lSUP grade group 1 and grade groups 2-5.

RESULTS

PCI was assessed in 185 patients (25.1%) and PCA in 361 patients (48.9%) of whom 188 (25.5%) had ISUP grade and 173 (23.4%) had ISUP groups 2-5 tumors. PCI inversely related to ISUP groups (p < 0.0001). In multivariate analysis, the risk of ISUP grade group 1 PCA compared to negative cases associated positively with age (OR 1.042; p = 0.001) but inversely with total prostate volume (TPV; OR 0.965; p < 0.0001) and PCI (OR 0.314; p < 0.0001). Intermediate-high grade tumors associated positively with age (OR 1.065; p < 0.0001), prostate specific antigen (OR 1.167; p < 0.0001), and abnormal digital rectal examination (OR 2.251; p < 0.0001) but inversely with TPV (OR 0.921; p < 0.0001) and PCI (OR 0.106; p < 0.0001).

CONCLUSIONS

PCI decreased the risk of PCA among ISUP tumor grade groups.

摘要

目的

本研究旨在评估前列腺慢性炎症（PCI）与国际泌尿病理学会（ISUP）定义的前列腺癌（PCA）分级组之间的关联。

方法

本研究回顾性评估了738例病例。将患者人群分为3组，收集无PCA和有PCA的病例，包括ISUP分级组1以及分级组2 - 5的受试者。

结果

在185例患者（25.1%）中评估了PCI，361例患者（48.9%）中评估了PCA，其中188例（25.5%）有ISUP分级1级，173例（23.4%）有ISUP分级组2 - 5级肿瘤。PCI与ISUP分级组呈负相关（p < 0.0001）。在多变量分析中，与阴性病例相比，ISUP分级组1级PCA的风险与年龄呈正相关（OR 1.042；p = 0.001），但与前列腺总体积（TPV；OR 0.965；p < 0.0001）和PCI呈负相关（OR 0.314；p < 0.0001）。中高分级肿瘤与年龄呈正相关（OR 1.065；p < 0.0001）、前列腺特异性抗原呈正相关（OR 1.167；p < 0.0001）以及直肠指检异常呈正相关（OR 2.251；p < 0.0001），但与TPV呈负相关（OR 0.921；p < 0.0001）和PCI呈负相关（OR 0.106；p < 0.0001）。