Tagliaferri Luca, Bussu Francesco, Fionda Bruno, Catucci Francesco, Rigante Mario, Gambacorta Maria Antonietta, Autorino Rosa, Mattiucci Gian Carlo, Miccichè Francesco, Placidi Elisa, Balducci Mario, Galli Jacopo, Paludetti Gaetano, Kovacs György, Valentini Vincenzo
Department of Radiation Oncology, Catholic University, Rome - Italy.
Department of Otorhinolaryngology, Catholic University, Rome - Italy.
Tumori. 2017 Nov 23;103(6):516-524. doi: 10.5301/tj.5000614. Epub 2017 Mar 8.
The aim of our study was to evaluate the outcomes of patients reirradiated with high-dose-rate (HDR) intensity-modulated brachytherapy (IMBT) for recurrent head and neck cancer and to perform a systematic review of the literature.
Patients treated with prior radiation doses >65 Gy were considered. After resection of macroscopic disease, catheters were fixed to the tumor bed. The total dose was 30 Gy in 12 fractions of 2.5 Gy twice daily for 5 days a week. A systematic literature search was conducted through several electronic databases including Medline/PubMed, Scopus, Embase and the Cochrane library.
Seventeen patients were included; median overall survival was 19 months with a median local control interval of 15 months. Median follow-up was 36 months. Seven papers were considered for the review.
IMBT could play an important role in the retreatment of recurrent head and neck cancer.
我们研究的目的是评估接受高剂量率（HDR）调强近距离放射治疗（IMBT）的复发性头颈癌患者的治疗结果，并对文献进行系统综述。
考虑曾接受过大于65 Gy放射剂量治疗的患者。在肉眼可见的病灶切除后，将导管固定于瘤床。总剂量为30 Gy，分12次给予，每次2.5 Gy，每天两次，每周5天。通过多个电子数据库进行系统文献检索，包括Medline/PubMed、Scopus、Embase和Cochrane图书馆。
纳入17例患者；中位总生存期为19个月，中位局部控制期为15个月。中位随访时间为36个月。7篇论文纳入综述。
IMBT在复发性头颈癌的再治疗中可发挥重要作用。
