Jia Linpei, Zhang Weiguang, Ma Jie, Chen Xizhao, Chen Lei, Li Zuoxiang, Cai Guangyan, Huang Jing, Zhang Jinping, Bai Xiaojuan, Feng Zhe, Sun Xuefeng, Chen Xiangmei
Department of Nephrology, Second Hospital of Jilin University, Changchun, China.
Department of Nephrology, Chinese People's Liberation Army General Hospital, Chinese People's Liberation Army Institute of Nephrology, State Key Laboratory of Kidney Disease, National Clinic Research Center for Kidney Diseases, Beijing, China.
Kidney Blood Press Res. 2017;42(1):43-51. doi: 10.1159/000468531. Epub 2017 Mar 13.
BACKGROUND/AIMS: In this study, we aim to investigate the association between renal function and arterial stiffness in a Chinese Han population, and further to discuss the effects of smoking on renal function.
We collected the data of the brachium-ankle pulse wave velocity (baPWV), blood pressure, blood chemistry and smoking status. Then, the multiple linear regression was done to explore the relationship between estimated glomerular filtration (eGFR) and baPWV. Further, the parameters were compared among the four groups divided according to the quartiles of baPWV. Finally, the baPWV, eGFR and albuminuria values were compared between smokers and non-smokers.
baPWV is associated with eGFR in the correlation analysis and univariate linear regression model. After adjustment, the pulse pressure (PP) instead of baPWV showed a significant association with eGFR. Nevertheless, the eGFR values differed among the four baPWV groups; the baPWV values were significantly higher in the subjects at the CKD (eGFR<60 mL/min/1.73 m2) and the early CKD stage (eGFR60-80 mL/min/1.73 m2). The baPWV values and the ratio of proteinuria were significantly increased in smokers.
PP but not baPWV is a predictor of declined renal function. Smokers have worse arterial stiffness and worse renal function.
背景/目的：在本研究中，我们旨在调查中国汉族人群中肾功能与动脉僵硬度之间的关联，并进一步探讨吸烟对肾功能的影响。
我们收集了肱踝脉搏波速度（baPWV）、血压、血液生化和吸烟状况的数据。然后，进行多元线性回归以探讨估算肾小球滤过率（eGFR）与baPWV之间的关系。此外，根据baPWV的四分位数将研究对象分为四组，并比较了这四组之间的参数。最后，比较了吸烟者与非吸烟者之间的baPWV、eGFR和蛋白尿值。
在相关性分析和单变量线性回归模型中，baPWV与eGFR相关。调整后，与eGFR显著相关的是脉压（PP）而非baPWV。然而，eGFR值在四个baPWV组之间存在差异；在慢性肾脏病（CKD，eGFR<60 mL/min/1.73 m2）和慢性肾脏病早期（eGFR 60-80 mL/min/1.73 m2）阶段的受试者中，baPWV值显著更高。吸烟者的baPWV值和蛋白尿比例显著升高。
预测肾功能下降的指标是PP而非baPWV。吸烟者的动脉僵硬度更差，肾功能也更差。
