Cui Si Lu, Liu Peng, Su Xiao Hui, Liu Shou Jun
Institute for Iodine Deficiency Disorders Control, Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin 150081, Heilongjiang, China.
Biomed Environ Sci. 2017 Feb;30(2):88-96. doi: 10.3967/bes2017.012.
We aimed to evaluate goiter prevalence and iodine nutritional status in areas with high levels of water iodine; to monitor the prevalence of iodine deficiency disorders (IDD) in areas at high risk of IDD; and to compare the prevalence of goiter and urine iodine (UI) concentrations between children living in the two areas.
Based on surveillance from 2012-2014, we analyzed the concentration of UI and prevalence of goiter in 8-10-year-old children from 12 high-risk IDD provinces, and from 8 provinces and municipalities with excessive water iodine. We calculated goiter prevalence for each UI level according to World Health Organization (WHO) standards and constructed predictive prevalence curves.
The goiter prevalence and median UI of children from areas with high water iodine were not optimal, being above the WHO standards (5% and 100-199 μg/L, respectively), whereas those in high-risk areas fell within the standard. UI and goiter prevalence exhibited a U-shaped relationship in high-risk endemic areas and a parabolic relationship in areas of iodine excess.
Iodine surplus in high-iodine areas leads to high goiter prevalence and UI. However, in high-risk areas, UI was optimal and goiter prevalence met the national criteria for IDD elimination.
我们旨在评估水碘含量高的地区的甲状腺肿患病率和碘营养状况；监测碘缺乏病（IDD）高风险地区的碘缺乏病患病率；并比较生活在这两个地区的儿童的甲状腺肿患病率和尿碘（UI）浓度。
基于2012 - 2014年的监测数据，我们分析了来自12个碘缺乏病高风险省份以及8个水碘过量的省份和直辖市的8 - 10岁儿童的尿碘浓度和甲状腺肿患病率。我们根据世界卫生组织（WHO）标准计算每个尿碘水平的甲状腺肿患病率，并构建预测患病率曲线。
水碘含量高的地区儿童的甲状腺肿患病率和尿碘中位数不理想，高于WHO标准（分别为5%和100 - 199μg/L），而高风险地区的情况则在标准范围内。在高风险流行地区，尿碘与甲状腺肿患病率呈U形关系，在碘过量地区呈抛物线关系。
高碘地区的碘过剩导致甲状腺肿患病率和尿碘升高。然而，在高风险地区，尿碘处于理想水平，甲状腺肿患病率符合国家消除碘缺乏病的标准。
