Alhowikan Abdulrahman Mohammed, ayadhi Laila Y. Al-, Alkhedaide Adel Q.
Department of Physiology, The Autism Research and Treatment Center, King Saud University, Riyadh, Saudi Arabia.
Department of Molecular Biology, Taif University, Taif, Saudi Arabia.
J Coll Physicians Surg Pak. 2017 Feb;27(2):84-87.
To determine the association of learning and memory calcineurin binding (CABIN1) protein with autism spectrum disorders.
Cross-sectional comparative study.
The Autism Research and Treatment Center, King Khalid University Hospital, Riyadh, Saudi Arabia, from October 2013 to May 2014.
Serum levels of CABIN1 protein in 62 (64%) autistic male children were analysed and 35 (36%) age healthy children measured by using ELISA. The diagnosis of autism was made, based on the criteria of autism as defined in the DSM-IV. CARS (childhood autism rating scale) was used for the assessment of autistic severity. Data was analysed on SPSS version 21. Mann-Whitney U-test was used for comparisons of CABIN1 protein levels between the autistic and control groups at a p-value of <0.05. Spearman's correlation coefficient (r) was used to determine the relationships between different variables.
There was no significant difference between the levels of CABIN1 between the 1.12 (0.01-8.8) pg/ml and healthy (1.51, 0.12-4.32) pg/ml in children. However, children with mild to moderate autism had higher CABIN1 protein level (1.27 pg/ml, 0.01-10.240) than children with severe autism (0.80 pg/ml, 0.01-4.25, p=0.145). In addition, there was no significant relationships among the serum level of CABIN1 protein, the CARS score, and age.
CABIN1 protein level for children with autism was not significantly different from controls subjects as well as between children with mild to moderate and severe autism.
确定学习与记忆钙调神经磷酸酶结合蛋白（CABIN1）与自闭症谱系障碍之间的关联。
横断面比较研究。
沙特阿拉伯利雅得国王哈立德大学医院自闭症研究与治疗中心，2013年10月至2014年5月。
采用酶联免疫吸附测定法（ELISA）分析62名（64%）自闭症男童的血清CABIN1蛋白水平，并测定35名（36%）年龄匹配的健康儿童的血清CABIN1蛋白水平。根据《精神疾病诊断与统计手册》第四版（DSM-IV）中定义的自闭症标准进行自闭症诊断。使用儿童自闭症评定量表（CARS）评估自闭症严重程度。数据采用SPSS 21版进行分析。采用曼-惠特尼U检验比较自闭症组与对照组之间的CABIN1蛋白水平（p值<0.05）。使用斯皮尔曼相关系数（r）确定不同变量之间的关系。
儿童自闭症组的CABIN1水平为1.12（0.01 - 8.8）pg/ml，健康组为1.51（0.12 - 4.32）pg/ml，两者之间无显著差异。然而，轻度至中度自闭症儿童的CABIN1蛋白水平（1.27 pg/ml，0.01 - 10.240）高于重度自闭症儿童（0.80 pg/ml，0.01 - 4.25，p = 0.145）。此外，CABIN1蛋白血清水平、CARS评分和年龄之间无显著关系。
自闭症儿童的CABIN1蛋白水平与对照组以及轻度至中度和重度自闭症儿童之间均无显著差异。
