Halepoto Dost Muhammad, Alhowikan Abdulrahman Mohammed, Ayadhi Laila Al-
Autism Research and Treatment Center, Al-Amodi Autism Research Chair, King Saud University, Riyadh-11461, Saudi Arabia.
Autism Research and Treatment Center, Al-Amodi Autism Department of Physiology, Faculty of Medicine, King Saud University, Riyadh-11461, Saudi Arabia.
J Coll Physicians Surg Pak. 2017 Mar;27(3):149-152.
To investigate the cluster of differentiation 5 (CD5) plasma levels and their association with childhood autism rating scale (CARS) in subjects with autism spectrum disorder (ASD) compared to age and gender matched healthy controls, and to explore the link between CD5, severity, and autoimmunity in autism.
Case-control study.
Autism Research and Treatment Center, Al-Amodi Autism Research Chair, Department of Physiology, Faculty of Medicine, King Khalid University Hospital, King Saud University, Riyadh, Saudi Arabia, from October 2014 to May 2015.
CD5 levels were determined in the plasma of thirty-one (31) patients using enzyme-linked immunosorbent assay (ELISA), categorized as mild-moderate and severe as indicated by their Childhood Autism Rating Scale (CARS) score and compared to thirty-three (33) age and gender-matched control samples.
The preliminary data indicated that children with severe autism (n=12), exhibited significantly (p=0.02) higher plasma level of CD5 [0.55 (0.14-12) pg/ml {median (interquartile range=IQR)}] than those of normal controls [n=33, 0.29 (0.08-0.79) pg/ml {median (IQR)}] and children with mild to moderate autism [n=19, 0.26 (0.13-1.42) pg/ml, {median (IQR)}, p=0.08]. However, there was no significant difference between the CD5 levels of children with mild to moderate autism and normal controls (p = 0.62). Diagnoses of autistic children based on the CARS score >30. Disease severity and the CARS score, which represent stereotyped patterns of behavior in children with autism, were positively correlated (r = 0.43, p = 0.02).
The high CD5 plasma levels in patients with severe ASD, probably indicated that CD5 might be implicated in the physiology of autism. However, this finding should be treated with caution until further investigations are performed with larger populations to determine whether the increase in plasma CD5 levels is a mere consequence of autism or it plays a pathogenic role in the disease.
与年龄和性别匹配的健康对照相比，研究自闭症谱系障碍（ASD）患者的分化簇5（CD5）血浆水平及其与儿童自闭症评定量表（CARS）的关联，并探讨CD5、严重程度和自闭症自身免疫之间的联系。
病例对照研究。
沙特阿拉伯利雅得国王沙特大学国王哈立德大学医院生理学系阿穆迪自闭症研究主席自闭症研究与治疗中心，2014年10月至2015年5月。
采用酶联免疫吸附测定（ELISA）法测定31例患者血浆中的CD5水平，根据儿童自闭症评定量表（CARS）评分将其分为轻度-中度和重度，并与33例年龄和性别匹配的对照样本进行比较。
初步数据表明，重度自闭症儿童（n = 12）的血浆CD5水平[0.55（0.14 - 12）pg/ml {中位数（四分位间距=IQR）}]显著高于正常对照组[n = 33，0.29（0.08 - 0.79）pg/ml {中位数（IQR）}]和轻度至中度自闭症儿童[n = 19，0.26（0.13 - 1.42）pg/ml，{中位数（IQR）}，p = 0.08]（p = 0.02）。然而，轻度至中度自闭症儿童与正常对照组的CD5水平之间无显著差异（p = 0.62）。根据CARS评分>30对自闭症儿童进行诊断。疾病严重程度和代表自闭症儿童刻板行为模式的CARS评分呈正相关（r = 0.43，p = 0.02）。
重度ASD患者血浆CD5水平较高，这可能表明CD5可能与自闭症的生理机制有关。然而，在对更多人群进行进一步研究以确定血浆CD5水平升高是自闭症的单纯结果还是在疾病中起致病作用之前，这一发现应谨慎对待。
