Khan Faisal Aziz, Awais Mohammed, Niazi Shafaq Pervez Khan, Akhter Naveed, Ishaq Mazhar
Department of Ophthalmology, Combined Military Hospital, Sargodha.
Department of Ophthalmology, Rai Medical College, Sargodha.
J Coll Physicians Surg Pak. 2017 Feb;27(2):88-91.
To compare the effectiveness of preoperative subconjunctival injection of Mitomycin-C at 24-hour and at one month before primary pterygium excision.
Randomised controlled trial.
Eye Department, Combined Military Hospital, Sargodha, from January to December 2014.
Eyes of 60 patients were randomly allocated into two equal groups (A and B) of 30 each. In group A Mitomycin-C was injected into the pterygium one month before, and in group B Mitomycin-C was injected 24 hours before excision. All pterygia received 0.1 ml of Mitomycin-C in a concentration of 0.15 mg/ml. Primary pterygia greater or equal to 2.5 mm were selected and excised as a bare sclera technique. Postoperatively, all patients were followed-up for 06 months. The recurrence and corneoscleral complications were recorded. Pearson chi-square test was used to compare the recurrence between group A and group B.
The recurrence of pterygium in group A was 3.3%; and in group B, it was 6.7%. Comparison of the recurrences between both the groups was statistically insignificant, (p=0.554).Postoperatively, no serious corneoscleral complications occurred in either group.
The preoperative subconjunctival injection of Mitomycin-C in a dose of 0.15 mg/ml given 24 hours prior to excision is as effective as 01 month preoperative injection for primary pterygium surgery with bare sclera technique.
比较原发性翼状胬肉切除术前24小时和1个月结膜下注射丝裂霉素C的效果。
随机对照试验。
2014年1月至12月，萨戈达联合军事医院眼科。
将60例患者的眼睛随机分为两组，每组30只眼睛（A组和B组）。A组在翼状胬肉切除术前1个月注射丝裂霉素C，B组在切除术前24小时注射丝裂霉素C。所有翼状胬肉均接受浓度为0.15mg/ml的丝裂霉素C 0.1ml。选择大小大于或等于2.5mm的原发性翼状胬肉，采用裸巩膜技术切除。术后对所有患者进行6个月的随访。记录复发情况及角膜巩膜并发症。采用Pearson卡方检验比较A组和B组的复发率。
A组翼状胬肉复发率为3.3%；B组为6.7%。两组复发率比较差异无统计学意义（p=0.554）。术后两组均未发生严重的角膜巩膜并发症。
对于采用裸巩膜技术的原发性翼状胬肉手术，术前24小时结膜下注射0.15mg/ml丝裂霉素C与术前1个月注射的效果相同。
