ETO2-GLIS2：一种嵌合转录因子通过新生转录网络驱动白血病发生。
ETO2-GLIS2: A Chimeric Transcription Factor Drives Leukemogenesis through a Neomorphic Transcription Network.
机构信息
Department of Cell Biology, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY 10461, USA.
Department of Cell Biology, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY 10461, USA; Department of Medicine, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY 10461, USA; Albert Einstein Cancer Center, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY 10461, USA; Ruth L. and David S. Gottesman Institute for Stem Cell Research and Regenerative Medicine, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY 10461, USA.
出版信息
Cancer Cell. 2017 Mar 13;31(3):307-308. doi: 10.1016/j.ccell.2017.02.015.
Acute megakaryoblastic leukemia (AMKL) is a heterogeneous disease with a relatively poorly understood pathogenesis. In this issue of Cancer Cell, Thirant and colleagues systematically examine unique transcriptional and functional effects of ETO2-GLIS2, an oncogenic fusion protein frequently encountered in AMKL, and elucidate a therapeutic vulnerability in this poor-prognosis leukemia.
急性巨核细胞白血病（AMKL）是一种具有相对较差发病机制的异质性疾病。在本期《癌细胞》中，Thirant 及其同事系统地研究了 AMKL 中常见的致癌融合蛋白 ETO2-GLIS2 的独特转录和功能效应，并阐明了这种预后不良白血病的治疗弱点。
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