Kusumoto Shinya, Naito Hiroyuki, Imazu Kunitomo, Kai Itsuka, Hamasaki Aki, Kazusa Yoshie, Nakashima Yumiko, Kodama Miho, Kumagai Masatoshi, Ueda Katsunori
Dept. of Obstetrics and Gynecology, Hiroshima Prefectural Hospital.
Gan To Kagaku Ryoho. 2017 Mar;44(3):255-259.
A standard regimen for ovarian malignant germ cell tumors is bleomycin, etoposide, cisplatin(BEP)chemotherapy. Adherence to a treatment schedule of every 21 days has been reported to be important. However, the incidence of febrile neutropenia( FN)and the optimaluse of granulocyte-colony stimulating factor(G-CSF)are unclear because of the low incidence of ovarian malignant germ cell tumors. We experienced 2 cases of ovarian malignant germ cell tumors that received BEP therapy after fertility-conserving surgery. In 1 case, we delayed drug administration in the first cycle because of FN. However, in order to maintain dose intensity(DI), we performed chemotherapy every 21 days by shortening the rest period. Myelosuppression may be severe in the first cycle of BEP therapy; however, it may be possible to adhere to the treatment schedule by using primary prophylactic administration of G-CSF.
卵巢恶性生殖细胞肿瘤的标准治疗方案是博来霉素、依托泊苷、顺铂（BEP）化疗。据报道，坚持每21天的治疗计划很重要。然而，由于卵巢恶性生殖细胞肿瘤的发病率较低，发热性中性粒细胞减少症（FN）的发生率以及粒细胞集落刺激因子（G-CSF）的最佳使用尚不清楚。我们遇到了2例卵巢恶性生殖细胞肿瘤患者，她们在保留生育功能的手术后接受了BEP治疗。在1例患者中，由于FN，我们在第一个周期延迟了药物给药。然而，为了维持剂量强度（DI），我们通过缩短休息时间每21天进行一次化疗。BEP治疗的第一个周期骨髓抑制可能很严重；然而，通过使用G-CSF进行一级预防性给药，有可能坚持治疗计划。
