Ma Xiang-Yun, Wang Yong-Jun, Xu Bo, Feng Kun, Sun Gao-Xiang, Zhang Xiao-Qian, Liu Xiao-Min, Shen Chen-Yu, Ren Xia-Jin, Sun Jing-Jing, Liu Po-Zi
Medical Center, Tsinghua University, Beijing, China; YuQuan Hospital, Tsinghua University, Beijing, China.
Tianjin Anding Hospital, Tianjin, China.
Dis Markers. 2017;2017:1695930. doi: 10.1155/2017/1695930. Epub 2017 Feb 14.
. Menopausal depression (MD) is characterized by depressive symptoms along with hormonal fluctuations. We investigate brain function alteration between major depressive disorder (MDD) and MD. . The difference in oxygenated hemoglobin (Oxy-Hb) for the prefrontal cortex (PFC) was compared retrospectively among 90 females presented with 30 MDD, 30 MD, and 30 healthy controls (HCs) using verbal fluency task (VFT) with near-infrared spectroscopy (NIRS). . We observed a significant difference in Oxy-Hb alteration in the left dorsolateral PFC (DLPFC) using VFT with NIRS (channel 18, = 0.007) between the MD and MDD groups. A significant difference in Oxy-Hb levels was observed among the three groups in the bilateral DLPFC (channels 18, 27, 33, 39, 41, and 45; < 0.05). Compared to the HCs, the MD group presented lower Oxy-Hb activation in the right DLPFC (channel 41; = 0.048) and the left DLPFC (channels 18, 39, and 45; < 0.05), and the MDD group presented lower Oxy-Hb activation in the right DLPFC (channels 27, 33, and 41; < 0.05) and the left DLPFC (channels 39 and 45; < 0.05). . Abnormal hemodynamics of the left DLPFC can differentiate MD from MDD by NIRS.
更年期抑郁症（MD）的特征是抑郁症状伴随激素波动。我们研究了重度抑郁症（MDD）和MD之间的脑功能改变。使用近红外光谱（NIRS）的言语流畅性任务（VFT），对90名女性进行回顾性比较，其中30名患有MDD，30名患有MD，30名是健康对照（HCs），比较她们前额叶皮质（PFC）的氧合血红蛋白（Oxy-Hb）差异。我们观察到，在MD组和MDD组之间，使用NIRS的VFT（通道18，P = 0.007）时，左侧背外侧前额叶皮质（DLPFC）的Oxy-Hb改变存在显著差异。在双侧DLPFC的三个组之间观察到Oxy-Hb水平存在显著差异（通道18、27、33、39、41和45；P < 0.05）。与HCs相比，MD组右侧DLPFC（通道41；P = 0.048）和左侧DLPFC（通道18、39和45；P < 0.05）的Oxy-Hb激活较低，MDD组右侧DLPFC（通道27、33和41；P < 0.05）和左侧DLPFC（通道39和45；P < 0.05）的Oxy-Hb激活较低。左侧DLPFC的异常血流动力学可以通过NIRS区分MD和MDD。
