局部用阿托品控制近视
Topical Atropine in the Control of Myopia.
作者信息
Galvis Virgilio, Tello Alejandro, Parra M Margarita, Merayo-Lloves Jesus, Larrea Jaime, Julian Rodriguez Carlos, Camacho Paul Anthony
机构信息
Centro Oftalmologico Virgilio Galvis, Floridablanca, Colombia; Faculty of Health Sciences, Universidad Autonoma de Bucaramanga (UNAB), Floridablanca, Colombia.
Instituto Universitario Fernandez-Vega Oviedo, Spain.
出版信息
Med Hypothesis Discov Innov Ophthalmol. 2016 Fall;5(3):78-88.
Abstract
Atropine has been used for more than a century to arrest myopia progression. Compelling evidence of its protective effect has been reported in well-designed clinical studies, mainly performed during the last two decades. However, its exact mechanism of action has not been determined. Experimental findings have shown that the mechanism is not related to accommodation, as was thought for decades. A review of the published literature revealed a significant amount of evidence supporting its safety and efficacy at a concentration of 1.0%, and at lower concentrations (as low as 0.01%).
摘要
一个多世纪以来，阿托品一直被用于阻止近视进展。在精心设计的临床研究中已经报告了其保护作用的确凿证据，这些研究主要在过去二十年中进行。然而，其确切的作用机制尚未确定。实验结果表明，该机制与调节无关，而几十年来人们一直认为它与调节有关。对已发表文献的综述显示，有大量证据支持其在1.0%的浓度以及更低浓度（低至0.01%）时的安全性和有效性。
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Br J Ophthalmol. 2016 Nov;100(11):1525-1529. doi: 10.1136/bjophthalmol-2015-307861. Epub 2016 Feb 22.
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