• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

The substitution V379I in PA protein attenuates the pathogenicity of influenza A (H1N1) pdm09 viruses in mice.

作者信息

Chen Yongkun, Zhu Wenfei, Bai Tian, Zou Xiaohui, Zhang Siyu, Sun Yan, Li Xiyan, Xiang Xingyu, Zhao Qinglong, Huang Chaoyang, Chen Tao, Wang Dayan, Shu Yuelong

机构信息

National Institute for Viral Disease Control and Prevention, Collaboration Innovation Center for Diagnosis and Treatment of Infectious Diseases, Chinese Center for Disease Control and Prevention; Key Laboratory for Medical Virology, National Health and Family Planning Commission, Beijing, 102206, China.

Hunan Provincial Center for Disease Control and Prevention, Changsha, 410005, China.

出版信息

Sci China Life Sci. 2017 Sep;60(9):1044-1046. doi: 10.1007/s11427-016-9018-8. Epub 2017 Mar 13.

DOI:10.1007/s11427-016-9018-8
PMID:28293812
Abstract
摘要

相似文献

1
The substitution V379I in PA protein attenuates the pathogenicity of influenza A (H1N1) pdm09 viruses in mice.PA蛋白中的V379I替换降低了甲型流感（H1N1）pdm09病毒在小鼠中的致病性。
Sci China Life Sci. 2017 Sep;60(9):1044-1046. doi: 10.1007/s11427-016-9018-8. Epub 2017 Mar 13.
2
Impact of the Baloxavir-Resistant Polymerase Acid I38T Substitution on the Fitness of Contemporary Influenza A(H1N1)pdm09 and A(H3N2) Strains.抗病毒药物耐药聚合酶酸性 I38T 取代对当代甲型流感 A(H1N1)pdm09 和 A(H3N2) 株适应性的影响。
J Infect Dis. 2020 Jan 1;221(1):63-70. doi: 10.1093/infdis/jiz418.
3
[Mutations in Hemagglutinin and Polymerase Alter the Virulence of Pandemic A(H1N1) Influenza Virus].[血凝素和聚合酶突变改变甲型H1N1流感大流行病毒的毒力]
Mol Biol (Mosk). 2018 Jul-Aug;52(4):644-658. doi: 10.1134/S0026898418040055.
4
Swine Influenza Virus PA and Neuraminidase Gene Reassortment into Human H1N1 Influenza Virus Is Associated with an Altered Pathogenic Phenotype Linked to Increased MIP-2 Expression.猪流感病毒PA和神经氨酸酶基因重配入人H1N1流感病毒与一种与MIP-2表达增加相关的致病性表型改变有关。
J Virol. 2015 May;89(10):5651-67. doi: 10.1128/JVI.00087-15. Epub 2015 Mar 11.
5
The R251K Substitution in Viral Protein PB2 Increases Viral Replication and Pathogenicity of Eurasian Avian-like H1N1 Swine Influenza Viruses.R251K 取代病毒蛋白 PB2 增加了欧亚类禽 H1N1 猪流感病毒的病毒复制和致病性。
Viruses. 2020 Jan 2;12(1):52. doi: 10.3390/v12010052.
6
Substitution of D701N in the PB2 protein could enhance the viral replication and pathogenicity of Eurasian avian-like H1N1 swine influenza viruses.D701N 取代 PB2 蛋白可增强欧亚类禽源性 H1N1 猪流感病毒的复制和致病性。
Emerg Microbes Infect. 2018 May 2;7(1):75. doi: 10.1038/s41426-018-0073-6.
7
Functional Evolution of the 2009 Pandemic H1N1 Influenza Virus NS1 and PA in Humans.人类 2009 年大流行性 H1N1 流感病毒 NS1 和 PA 的功能进化。
J Virol. 2018 Sep 12;92(19). doi: 10.1128/JVI.01206-18. Print 2018 Oct 1.
8
Molecular Determinants of Virulence and Stability of a Reporter-Expressing H5N1 Influenza A Virus.表达报告基因的H5N1甲型流感病毒毒力和稳定性的分子决定因素
J Virol. 2015 Nov;89(22):11337-46. doi: 10.1128/JVI.01886-15. Epub 2015 Sep 2.
9
A Y161F Hemagglutinin Substitution Increases Thermostability and Improves Yields of 2009 H1N1 Influenza A Virus in Cells.Y161F血凝素替换增加了2009年甲型H1N1流感病毒在细胞中的热稳定性并提高了产量。
J Virol. 2018 Jan 2;92(2). doi: 10.1128/JVI.01621-17. Print 2018 Jan 15.
10
Effects of a hemagglutinin D222G substitution on the pathogenicity of 2009 influenza A (H1N1) virus in mice.血凝素D222G置换对2009年甲型H1N1流感病毒在小鼠中致病性的影响。
Arch Virol. 2014 Oct;159(10):2559-65. doi: 10.1007/s00705-014-2104-5. Epub 2014 May 14.

引用本文的文献

1
Two amino acid residues in the N-terminal region of the polymerase acidic protein determine the virulence of Eurasian avian-like H1N1 swine influenza viruses in mice.聚合酶酸性蛋白 N 端区域的两个氨基酸残基决定了欧亚类禽 H1N1 猪流感病毒在小鼠中的毒力。
J Virol. 2024 Oct 22;98(10):e0129324. doi: 10.1128/jvi.01293-24. Epub 2024 Aug 30.
2
A host-based whole genome sequencing study reveals novel risk loci associated with severity of influenza A(H1N1)pdm09 infection.基于宿主的全基因组测序研究揭示了与甲型流感 A(H1N1)pdm09 感染严重程度相关的新风险位点。
Emerg Microbes Infect. 2021 Dec;10(1):123-131. doi: 10.1080/22221751.2020.1870412.