Molecular analysis of HLA-DP specificities HLA-DPw1, -DPw2 and -DPw4: DP beta chain heterogeneity correlates with PLT subtyping. - Suppr | 超能文献

Molecular analysis of HLA-DP specificities HLA-DPw1, -DPw2 and -DPw4: DP beta chain heterogeneity correlates with PLT subtyping.

作者信息

Baas E J, Bontrop R E, Otting N, Giphart M J

机构信息

Department of Immunohaematology, University Hospital Leiden, The Netherlands.

出版信息

Tissue Antigens. 1988 Jan;31(1):5-13. doi: 10.1111/j.1399-0039.1988.tb02059.x.

DOI:10.1111/j.1399-0039.1988.tb02059.x

Abstract

HLA-DP molecules were isolated from Epstein-Barr virus transformed B cell lines by immunoprecipitation with monoclonal antibody B7/21.2 and subsequently analysed by two-dimensional gel electrophoresis. The results obtained demonstrate that the HLA-DP molecules that can be isolated from cells positive for the HLA-DP specificities HLA-DPw1, -DPw2 and -DPw4 display DP beta chain isoelectric point differences, whereas no DP alpha chain polymorphism was observed. These results suggest that the PLT defined HLA-DP specificities (HLA-DPw1, -DPw2 and -DPw4) are probably DP beta chain structures.

摘要

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