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绿色合成纳米材料作为癌症治疗的治疗诊断一体化平台:原理、挑战和未来的道路。

Green Synthesized Nanomaterials as Theranostic Platforms for Cancer Treatment: Principles, Challenges and the Road Ahead.

机构信息

Department of Biomedical and Pharmaceutical Sciences, School of Pharmacy, Chapman University, Irvine, California 92618-1908, United States.

State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen, 361102, China.

出版信息

Curr Med Chem. 2019;26(8):1311-1327. doi: 10.2174/0929867324666170309124327.

Abstract

With the emergence of nanotechnology, new methods have been developed for engineering various nanoparticles for biomedical applications. Nanotheranostics is a burgeoning research field with tremendous prospects for the improvement of diagnosis and treatment of various cancers. However, the development of biocompatible and efficient drug/gene delivery theranostic systems still remains a challenge. Green synthetic approach of nanoparticles with low capital and operating expenses, reduced environmental pollution and better biocompatibility and stability is a latest and novel field, which is advantageous over chemical or physical nanoparticle synthesis methods. In this article, we summarize the recent research progresses related to green synthesized nanoparticles for cancer theranostic applications, and we also conclude with a look at the current challenges and insight into the future directions based on recent developments in these areas.

摘要

随着纳米技术的出现,已经开发出了用于将各种纳米颗粒工程化为生物医学应用的新方法。纳米治疗学是一个新兴的研究领域,具有极大的改善各种癌症的诊断和治疗的前景。然而,开发具有生物相容性和高效的药物/基因递药治疗系统仍然是一个挑战。使用绿色合成方法制备纳米颗粒具有较低的资本和运营成本、减少环境污染以及更好的生物相容性和稳定性,是一个最新的新颖领域,优于化学或物理纳米颗粒合成方法。在本文中,我们总结了与癌症治疗应用相关的绿色合成纳米颗粒的最新研究进展,并根据这些领域的最新发展,对当前的挑战和未来的方向进行了展望。

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