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在表达立即早期蛋白ICP4温度敏感突变形式的连续细胞系中稳定转染的单纯疱疹病毒胸苷激酶基因的调控表达

Regulated expression of stably transfected herpes simplex virus thymidine kinase genes in continuous cell lines expressing a temperature-sensitive mutant form of the immediate-early protein ICP4.

作者信息

Pasick J M, Smiley J R

机构信息

Pathology Department, McMaster University, Hamilton, Ontario, Canada.

出版信息

Virology. 1988 Feb;162(2):490-3. doi: 10.1016/0042-6822(88)90493-x.

DOI:10.1016/0042-6822(88)90493-x
PMID:2829431
Abstract

We stably transfected the herpes simplex virus type 1 thymidine kinase gene into a continuous cell line expressing a temperature-sensitive form of the viral immediate-early protein ICP4. In these cells, expression of the thymidine kinase gene was regulated in a temperature-sensitive manner, partially reproducing the controls that operate during a viral infection.

摘要

我们将单纯疱疹病毒1型胸苷激酶基因稳定转染至一个连续细胞系，该细胞系表达病毒立即早期蛋白ICP4的温度敏感型。在这些细胞中，胸苷激酶基因的表达以温度敏感的方式受到调控，部分重现了病毒感染期间发挥作用的调控机制。

相似文献

1
Regulated expression of stably transfected herpes simplex virus thymidine kinase genes in continuous cell lines expressing a temperature-sensitive mutant form of the immediate-early protein ICP4.在表达立即早期蛋白ICP4温度敏感突变形式的连续细胞系中稳定转染的单纯疱疹病毒胸苷激酶基因的调控表达
Virology. 1988 Feb;162(2):490-3. doi: 10.1016/0042-6822(88)90493-x.
2
Co-ordinate regulation of herpes simplex virus gene expression is mediated by the functional interaction of two immediate early gene products.单纯疱疹病毒基因表达的协同调控是由两种立即早期基因产物的功能相互作用介导的。
J Mol Biol. 1986 Oct 5;191(3):395-409. doi: 10.1016/0022-2836(86)90135-x.
3
In cell lines constitutively synthesizing a temperature-sensitive ICP4 protein of herpes simplex virus type 1, amount and function of ICP4 are both regulated by temperature.
Virology. 1987 Jun;158(2):285-93. doi: 10.1016/0042-6822(87)90200-5.
4
Association of herpes simplex virus regulatory protein ICP4 with sequences spanning the ICP4 gene transcription initiation site.单纯疱疹病毒调节蛋白ICP4与跨越ICP4基因转录起始位点的序列的关联。
Nucleic Acids Res. 1988 Jan 25;16(2):555-70. doi: 10.1093/nar/16.2.555.
5
Transcriptional induction of the ubiquitin gene during herpes simplex virus infection is dependent upon the viral immediate-early protein ICP4.单纯疱疹病毒感染期间泛素基因的转录诱导依赖于病毒即刻早期蛋白ICP4。
Nucleic Acids Res. 1987 Sep 25;15(18):7283-93. doi: 10.1093/nar/15.18.7283.
6
Activities of herpes simplex virus type 1 (HSV-1) ICP4 genes specifying nonsense peptides.1型单纯疱疹病毒（HSV-1）指定无义肽的ICP4基因的活性。
Nucleic Acids Res. 1987 Jun 11;15(11):4491-511. doi: 10.1093/nar/15.11.4491.
7
Activation of immediate-early, early, and late promoters by temperature-sensitive and wild-type forms of herpes simplex virus type 1 protein ICP4.1型单纯疱疹病毒蛋白ICP4的温度敏感型和野生型形式对即刻早期、早期和晚期启动子的激活作用
Mol Cell Biol. 1985 Aug;5(8):1997-2008. doi: 10.1128/mcb.5.8.1997-2008.1985.
8
Cloning of the herpes simplex virus ICP4 gene in an adenovirus vector: effects on adenovirus gene expression and replication.单纯疱疹病毒ICP4基因在腺病毒载体中的克隆：对腺病毒基因表达和复制的影响。
Virology. 1989 Feb;168(2):378-87. doi: 10.1016/0042-6822(89)90279-1.
9
Correlation of the virus sequence content and biological properties of cells carrying the herpes simplex virus type 2 thymidine kinase gene.
J Gen Virol. 1982 Jan;58 Pt 1:127-38. doi: 10.1099/0022-1317-58-1-127.
10
Transfer and expression of the lacZ gene in rat brain neurons mediated by herpes simplex virus mutants.单纯疱疹病毒突变体介导的lacZ基因在大鼠脑神经元中的转移与表达
New Biol. 1990 Aug;2(8):739-46.

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