Almeida J P, Lopes A, Campos Melo A, Pereira Santos M C, Pereira Barbosa M
Department of Immunoallergology, Santa Maria Hospital, Lisbon, Portugal Unit of Clinical Immunology, Institute of Molecular Medicine, Faculty of Medicine of Lisbon, Portugal. E-mail:
Department of Immunoallergology, Santa Maria Hospital, Lisbon, Portugal Unit of Clinical Immunology, Institute of Molecular Medicine, Faculty of Medicine of Lisbon, Portugal.
Eur Ann Allergy Clin Immunol. 2017 Mar;49(2):84-87.
The authors present 2 case reports of selective cefazolin hypersensitivity: a 49 year-old woman with a history of two perioperative reactions (urticaria and severe anaphylaxis) after the use of rocuronium, propophol and cefazolin; a 36 year-old pregnant woman who developed facial erythema, lips angioedema and hypotension immediately after administration of ropivacain, sufentanil, cefazolin, oxytocin and ephedrine. In both cases, intradermal skin tests were positive for cefazolin. A basophil activation test was performed for cefazolin, which was positive in one patient. Oral challenge tests with penicillin, amoxicillin and other cephalosporins were negative. This selective hypersensitivity to cefazolin may be associated with a R1-side chain different from other beta-lactams.
作者报告了2例头孢唑林选择性超敏反应的病例：一名49岁女性，在使用罗库溴铵、丙泊酚和头孢唑林后有两次围手术期反应（荨麻疹和严重过敏反应）病史；一名36岁孕妇，在给予罗哌卡因、舒芬太尼、头孢唑林、缩宫素和麻黄碱后立即出现面部红斑、唇部血管性水肿和低血压。在这两例病例中，头孢唑林皮内皮肤试验均为阳性。对头孢唑林进行了嗜碱性粒细胞活化试验，其中1例患者呈阳性。青霉素、阿莫西林和其他头孢菌素的口服激发试验均为阴性。这种对头孢唑林的选择性超敏反应可能与不同于其他β-内酰胺类药物的R1侧链有关。
