Juengst Shannon B, Myrga John M, Fann Jesse R, Wagner Amy K
From the Department of Physical Medicine and Rehabilitation, University of Pittsburgh School of Medicine, Pittsburgh (S.B.J., J.M.M., A.K.W.); and the Departments of Psychiatry and Behavioral Sciences, Rehabilitation Medicine, and Epidemiology, University of Washington, Seattle (J.R.F.).
J Neuropsychiatry Clin Neurosci. 2017 Summer;29(3):260-266. doi: 10.1176/appi.neuropsych.16100217. Epub 2017 Mar 15.
Timely treatment of depression and behavioral dysfunction after moderate-to-severe traumatic brain injury (TBI) could improve health, function, and quality of life. The authors hypothesized that 6-month depression would be the stronger contributor to later depression and behavioral dysfunction in a sample of 88 adults with moderate-to-severe TBI. A structural equation modeling cross-lagged panel analysis, adjusting for all 6-month predictors, revealed that 6-month depression had a stronger relationship to 12-month depression (β=0.55, p=0.002) and behavioral dysfunction (β=0.41, p=0.004) than did 6-month behavioral dysfunction (β=0.17, p=0.270, β=0.30, p=0.035). Depression may be in the developmental pathway to behavioral dysfunction, triggering a cycle of reciprocal causality.
对中重度创伤性脑损伤（TBI）后的抑郁症和行为功能障碍进行及时治疗，可改善健康状况、功能和生活质量。作者推测，在88名中重度TBI成年患者样本中，6个月时的抑郁症对后期抑郁症和行为功能障碍的影响更大。一项结构方程模型交叉滞后面板分析，在对所有6个月时的预测因素进行调整后发现，与6个月时的行为功能障碍相比，6个月时的抑郁症与12个月时的抑郁症（β=0.55，p=0.002）及行为功能障碍（β=0.41，p=0.004）的关系更为密切（6个月时行为功能障碍与12个月时抑郁症的β=0.17，p=0.270；与12个月时行为功能障碍的β=0.30，p=0.035）。抑郁症可能处于行为功能障碍的发展路径中，引发相互因果关系的循环。
